G6PD and tumors

doi:10.3760/cma.j.cn371439-20200401-00109

Abstract

Abstract:

Glucose-6-phosphate dehydrogenase (G6PD) is the key enzyme of the pentose phosphate pathway, participating in several metabolic processes and redox balance. Recently, studies show that kinds of tumor tissues have a high level of G6PD, which regulates cell proliferation and apoptosis, angiogenesis, metastasis and chemoradiotherapy resistance and plays a crucial role in tumor progression. Furthermore, G6PD may provide a promising therapeutic target for tumor.

Key words: Neoplasms, Phosphogluconate dehydrogenase, Neoplastic processes, Biomarkers

Wang Zhong, Li Zhiyu, Li Chenyuan, Sun Si, Sun Shengrong. G6PD and tumors[J]. Journal of International Oncology, 2020, 47(12): 728-731.

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G6PD and tumors

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