Uncoupling proteins and tumor

doi:10.3760/cma.j.cn371439-20200401-00100

Abstract

Abstract:

Uncoupling proteins (UCPs) belongs to the mitochondrial carrier protein family on the mitochondrial inner membrane, mainly including UCP1, UCP2 and UCP3. Studies have shown that UCPs participate in the occurrence and development of malignant tumors through lipid browning. Tumor cells secrete zinc-α2-glycoprotein to stimulate the peroxidosomal proliferator-activated receptor, induce lipid browning and express UCP1, and promote the growth of tumor. Phospholipase C-like 1 upregulates UCP1 expression, consumes abnormal lipids, reduces the ability of tumor cell colony formation, and inhibits tumor migration and invasion. In addition, PGC-1 α and PGC-1 β, the co-factors of tumor suppressor p53, can enhance the expression of UCP1 in p53-deficient adipose cells, and the up-regulation of UCP2 can help tumor cells escape apoptosis mediated by p53, activate the reactive oxygen species system, and enhance the vitality and proliferation of tumors.

Key words: Mitochondrial uncoupling proteins, Neoplasms, Peroxisome proliferator-activated receptors, Peroxisome proliferator-activated receptor γ coactivator-1α, Phospholipase C-like 1

Dai Yueyu, Song Qibin, Hu Weiguo. Uncoupling proteins and tumor[J]. Journal of International Oncology, 2020, 47(11): 682-685.

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