Interferon-related signaling pathways and clinical application in tumor therapy

doi:10.3760/cma.j.cn371439-20191230-00037

Abstract

Abstract:

Type Ⅰ, Ⅱ, Ⅲ interferons have anti-tumor potential, but the mechanism of action and clinical effect are different. Signaling pathways associated with interferon-treated tumors mainly include JAK-STAT, PI3K/AKT/mTOR, MAPK, NF-κB, c-Abl, etc. Type Ⅰ interferon has the widest clinical application and the most definite curative effect at present. Because of its serious adverse reaction and possible role in the process of cancer induction, type Ⅱ interferon has a great controversy on whether it can be used in anti-tumor therapy. The biological function of type Ⅲ interferon has good characteristics of type Ⅰ and Ⅱ interferon, but its anti-tumor medicinal value needs to be further evaluated.

Key words: Interferons, Neoplasms, Signal pathway, Clinical trial

Li Yuxiang, Wang Xinwen. Interferon-related signaling pathways and clinical application in tumor therapy[J]. Journal of International Oncology, 2020, 47(6): 364-367.

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