国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (10): 748-751.

• 综述 • 上一篇    下一篇

间充质干细胞作为载体在肿瘤治疗中的应用

李思雨,赵庆华   

  1. 200080 上海交通大学附属第一人民医院骨科
  • 出版日期:2012-10-31 发布日期:2012-10-31
  • 通讯作者: 赵庆华，E-mail:sawboneszhao@163.com E-mail:sawboneszhao@163.com
  • 基金资助:

    上海交通大学 “医工交叉研究基金”资助项目（YG2011MS28）

Mesenchymal stem cells as carriers in cancer therapy

 LI  Si-Yu, ZHAO  Qing-Hua   

  1. Department of Orthopaedic Surgery, Shanghai First People′s Hospital, Shanghai Jiaotong University, Shanghai 200080， China
  • Online:2012-10-31 Published:2012-10-31
  • Contact: ZHAO Qing-hua， E-mail:sawboneszhao@163.com E-mail:sawboneszhao@163.com

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摘要： 间充质干细胞(MSC)可以直接作用于肿瘤细胞，抑制其生长，并能特异性迁移到损伤部位和肿瘤组织，传递和表达多种抗肿瘤因子。诸多研究将MSC作为诱导肿瘤细胞凋亡、抑制肿瘤细胞分化、抑制肿瘤血管生成药物的载体，并取得了显著抗肿瘤效果。

关键词: 肿瘤, 基因疗法, 间充质干细胞

Abstract: Mesenchymal stem cells(MSCs) can directly act on tumor cells to inhibit their growth, and could also migrate to the tissue lesions and tumor tissues to transfer and express many kinds of anti-cancer factors. Numerous researches have applied MSCs as carriers of drugs to induce apoptosis, inhibit differentiation of tumor cells and inhibit tumor angiogenesis, and have got outstanding antitumor results.

Key words: Neoplasms, Gene therapy, Mesenchymal stem cells