国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (10): 751-754.

• 综述 • 上一篇    下一篇

上皮细胞黏附分子在肿瘤中的研究

张启,张洪涛,张树才   

  1. 101149 首都医科大学附属北京胸科医院肿瘤内科（张启，张树才）；北京市结核病胸部肿瘤研究所中心实验室（张洪涛）
  • 出版日期:2012-10-31 发布日期:2012-10-31
  • 通讯作者: 张树才，E-mail: zhangshucai6304@yahoo.com.cn E-mail:zhangshucai6304@yahoo.com.cn

Epithelial cell adhesion molecule and tumor

 ZHANG  Qi, ZHANG  Hong-Tao, ZHANG  Shu-Cai   

  1. Department of Oncology, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China
  • Online:2012-10-31 Published:2012-10-31
  • Contact: ZHANG Shu-cai, E-mail:zhangshucai6304@yahoo.com.cn E-mail:zhangshucai6304@yahoo.com.cn

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摘要： 上皮细胞黏附分子（EpCAM）是通过与核受体结合从而在基因表达调控过程中发挥重要作用。大量研究表明，EpCAM在乳腺癌、肺癌、胃癌等多种肿瘤呈过表达。EpCAM在肿瘤循环细胞富集、肿瘤发病机制以及预后作用中的研究，将有助于肿瘤靶向治疗取得新的突破。

关键词: 肿瘤, 抗体, 治疗, 上皮细胞黏附分子

Abstract: Epithelial cell adhesion molecules (EpCAMs) play an important role in the process of gene expression and regulation by combining with nuclear receptor. Aberrant expression of EpCAMs has been detected in different types of cancers, such as breast cancer, lung cancer, gastric cancer, and etc. The research of EpCAMs in circulating tumor cells enrichment, tumor pathogenesis and prognosis will be conducive to achieve new breakthroughs in cancer targeted therapy.

Key words: Neoplasms, Antibodies, Therapy, EpCAM