国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (10): 745-747.

• 综述 • 上一篇    下一篇

肿瘤干细胞及其微环境与肿瘤的耐药、复发和转移

周柰岑,徐波,刘心   

  1. 710061 西安交通大学医学院第一附属医院血液内科
  • 出版日期:2012-10-31 发布日期:2012-10-31
  • 通讯作者: 刘心,E-mail:liuxin59221@medmail.com.cn E-mail:liuxin59221@medmail.com.cn

The effect of neoplastic stem cell and microenvironment on tumor drug resistance,recurrence and metastasis

 ZHOU  Nai-Cen, XU  Bo, LIU  Xin   

  1. Department of Hematology, The First Affiliated Hospital, Medical School of Xi′an Jiaotong University, Xi′an  710061, China
  • Online:2012-10-31 Published:2012-10-31
  • Contact: LIU Xin, E-mail: liuxin59221@medmail.com.cn E-mail:liuxin59221@medmail.com.cn

摘要: 肿瘤干细胞(NSC)是肿瘤发生发展的根源,其特殊的微环境可通过调控NSC或者其自身变化参与肿瘤的耐药、复发和转移。根除NSC和干扰其特殊微环境可能是治疗肿瘤的新策略。

关键词: 肿瘤干细胞, 抗药性, 复发, 肿瘤转移, 肿瘤微环境

Abstract: Neoplastic stem cells(NSCs)are the source of tumor occurrence and development,and its special microenvironment  is  involved in tumor drug resistance,recurrence and metastasis by regulating NSCs or changing  itself. Eradicating NSCs and interfering the special microenvironment may be the new therapeutic strategies for cancer.

Key words: Neoplastic stem cells, Drug resistance, Recurrence, Neoplasm metastasis, Tumor microenvironment