基于表观遗传标志的液体活检在实体瘤诊疗中的研究与应用

doi:10.3760/cma.j.cn371439-20200918-00068

国际肿瘤学杂志 ›› 2021, Vol. 48 ›› Issue (6): 358-361.doi: 10.3760/cma.j.cn371439-20200918-00068

基于表观遗传标志的液体活检在实体瘤诊疗中的研究与应用

庄伟涛^1,², 乔贵宾¹()

¹广东省医学科学院广东省人民医院胸外科,广州 510080
²汕头大学医学院 515041

收稿日期:2020-09-18 修回日期:2020-09-26 出版日期:2021-06-08 发布日期:2021-06-24
通讯作者: 乔贵宾 E-mail:guibinqiao@126.com
基金资助:
广东省科技创新战略专项(2020A1414070007)

Research and application of liquid biopsy based on epigenetic markers in the diagnosis and treatment of solid tumors

Zhuang Weitao^1,², Qiao Guibin¹()

¹Department of Thoracic Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
²Shantou University Medical College, Shantou 515041, China

Received:2020-09-18 Revised:2020-09-26 Online:2021-06-08 Published:2021-06-24
Contact: Qiao Guibin E-mail:guibinqiao@126.com
Supported by:
Special Project for Technical Innovation Strategy of Guangdong Province of China(2020A1414070007)

摘要/Abstract

摘要：

表观遗传学改变与肿瘤发生、发展和转归密切相关,在肿瘤精准及微创诊疗方面具有很好的应用潜力。DNA甲基化、羟甲基化与组蛋白修饰检测技术的进步,推动了基于表观遗传标志的液体活检研究的开展,在实体肿瘤的溯源定位、早期诊断、临床分期、疗效评价、复发监测及预后判断方面均取得了重要进展。

关键词: 肿瘤, 生物标记, 表观基因组学, 液体活检

Abstract:

Epigenetic changes are closely related to carcinogenesis, tumor progression and prognosis, which have a considerable potential in assisting the precision and minimally invasive management of cancers. The progress of detection techniques for DNA methylation, hydroxymethylation and histone modification has promoted the research works of liquid biopsy targeting epigenetic markers, and recently, important progress has been made in tumor location, early diagnosis, clinical staging, evaluation of treatment response, monitoring of recurrence and prognostic prediction of solid tumors.

Key words: Neoplasms, Biomarkers,tumor, Epigenomics, Liquid biopsy

庄伟涛, 乔贵宾. 基于表观遗传标志的液体活检在实体瘤诊疗中的研究与应用[J]. 国际肿瘤学杂志, 2021, 48(6): 358-361.

Zhuang Weitao, Qiao Guibin. Research and application of liquid biopsy based on epigenetic markers in the diagnosis and treatment of solid tumors[J]. Journal of International Oncology, 2021, 48(6): 358-361.

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基于表观遗传标志的液体活检在实体瘤诊疗中的研究与应用

Research and application of liquid biopsy based on epigenetic markers in the diagnosis and treatment of solid tumors

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