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08 May 2018, Volume 45 Issue 5 Previous Issue    Next Issue

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Influences of platelet distribution width on the prognosis of patients with nasopharyngeal cancer ZHANG Xiang, ZHUANG Rui 2018, 45 (5):  257-261.  doi: 10.3760/cma.j.issn.1673422X.2018.05.001 Abstract ( 520 )   PDF (1975KB) ( 438 )   Save ObjectiveTo investigate the influences of platelet distribution width (PDW) on the prognosis of nasopharyngeal cancer patients. MethodsA total of 186 patients with nasopharyngeal cancer from January 2009 to December 2013 in our hospital were selected. The patients were aged from 48 to 79 years old, with an average age (61.8±8.2) years old. The age, gender, lung function, liver function, body mass index（BMI）, smoking, drinking, histological type  and staging of patients were recorded. The patients were followed up after discharge, and the mean follow up period was 28 months (1236 months). The terminal event was nasopharyngeal cancer related death or the end of follow up. The best threshold of receiver operating characteristic (ROC) curve for the overall survival rate of PDW was tested, and the patients were divided into ≥ best threshold group and ＜ best threshold group. The prognostic factors were analyzed by single factor analysis and Cox multiple regression analysis. ResultsThe best threshold of ROC curve for the overall survival rate of PDW was 16.4%. The patients were divided into PDW≥16.4% group and  PDW＜16.4% group. There were no statistically significant differences in age (t=0.712, P=0.478), gender (χ2=0.044, P=0.834), BMI (t=0.593, P=0.554), smoking (χ2=0.063, P=0.802), drinking (χ2=0.555, P=0.456), forced expiratory volume in one second/forced vital capacity (FEV1/FVC, t=1.711, P=0.089), alanine transaminase (ALT, t=1.756, P=0.081), histological type (χ2=0.259, P=0.879) and staging (Z=2.443, P=0.486) between the two groups. Results of single factor analysis showed that there were statistically significant differences in age (χ2=4.611, P=0.032), gender (χ2=3.952, P=0.047), smoking (χ2=5.564, P=0.018), FEV1/FVC (χ2=4.321, P=0.038), staging (χ2=6.021, P=0.014) and PDW (χ2=4.511, P=0.034) between the two groups. Cox risk model of multifactor analysis showed that the elderly (≥60 years, χ2=5.429, P=0.020), male patients (χ2=4.648, P=0.031), smoking (χ2=18.453, P<0.001), ⅢⅣ staging (χ2=9.612, P=0.002) and PDW≥16.4% (χ2=6.008, P=0.014) were independent prognostic factors in patients with nasopharyngeal cancer. ConclusionThe degree of PDW in patients with nasopharyngeal cancer affects the prognosis of patients, and the patients with PDW≥16.4% have the better prognosis. Related Articles | Metrics

Risk factors for postoperative lymphedema in breast cancer patients LIU Xiang-Wei, QU Yan-Yu, CHEN De-Dian 2018, 45 (5):  262-268.  doi: 10.3760/cma.j.issn.1673422X.2018.05.002 Abstract ( 675 )   PDF (2484KB) ( 464 )   Save ObjectiveTo investigate the risk factors of lymphedema in patients with breast cancer after operation. MethodsFrom January 2012 to May 2016, the clinical data of 350 patients with breast cancer who underwent surgical treatment in First People′s Hospital of Foshan were collected. According to the occurrence of postoperative lymphedema, the patients were divided into lymphedema group (87 cases) and non lymphedema group (263 cases). The possible risk factors were evaluated from general demographic indicators, pathological data of breast cancer, perioperative related data and preventive action implementation. Results General demographic data: there was no correlation between the incidence of lymphedema and age, preoperative body mass index (BMI), postoperative BMI, educational level, marital status, residence, family income, menopause, hypertension history (P＞0.05).  Pathological data of breast cancer: the occurrence of lymphedema was related with tumor quadrant (χ2=20.039, P＜0.001) and axillary lymph node metastasis (Z=4.713, P＜0.001), but not related with clinical stage and pathological type of tumor (both P≥0.05).  Perioperative data: the occurrence of lymphedema was related with the type of incision (χ2=16.921, P＜0.001), axillary lymph node dissection level (χ2=4.433, P＜0.001), the number of axillary lymph node dissection (Z=3.620, P＜0.001), radiotherapy (χ2=33.290, P＜0.001), endocrine therapy (χ2=10.428, P=0.001), but not related with surgical methods, postoperative complications (subcutaneous fluid, upper limbedema, infection, serum swelling), chemotherapy and neoadjuvant chemotherapy (all P＞0.05).  Comparison of preventive behaviors: avoiding injuries such as cuts and bites (χ2=15.754, P＜0.001), trimming nails (χ2=9.018,P=0.003), avoiding grasping heavy objects (χ2=11.828, P=0.001) were related with postoperative lymphedema, but other preventive behaviors did not show significant correlation (all P＞0.05).  Lymphedema as the dependent variable, multivariate logistic regression analysis results showed that tumor located in the upper outer quadrant (OR=3.943, P＜0.001), surgical incision for longitudinal incision (OR=3.767, P＜0.001) or oblique incision (OR=2.492, P＜0.001), Ⅱ (OR=1.707, P=0.003) or Ⅲ (OR=4.211, P＜0.001) axillary lymph node dissection, breast/chest wall radiotherapy (OR=2.869, P＜0.001) or lymph node radiotherapy (OR=4.829, P＜0.001), grabing heavy objects or not (OR=3.264, P＜0.001), avoiding injuries such as cuts and bites  (OR=2.602, P＜0.001) were independent risk influence factors of postoperative lymphedema. ConclusionA variety of factors affect the occurrence of postoperative lymphedema in breast cancer patients. Tumors located in the upper outer quadrant, longitudinal or oblique incision, high level of axillary lymph node dissection, radiotherapy, having  injuries such as cuts and bites, grabing heavy objects are independent risk influence factors of postoperative lymphedema in breast cancer patients.  More attention should be paid to the high risk of lymphedema, and the preventive measures should be taken actively. Related Articles | Metrics

Effect of platinum based dual drug secondline therapy on prognosis of NSCLC patients and relative factors analysis Wang Dazhong 2018, 45 (5):  269-272.  doi: 10.3760/cma.j.issn.1673422X.2018.05.003 Abstract ( 529 )   PDF (1775KB) ( 404 )   Save ObjectiveTo analyze the prognostic implications of secondline double drug regimens for advanced nonsmall cell lung cancer (NSCLC) patients and related factors. MethodsEighty patients with advanced NSCLC who were accepted from January 2014 to December 2016 in our hospital were chosen as the research objects. The patients were randomly divided into two groups using the random number table method, namely single drug group (n=40) and double drug group (n=40). The patients in single drug group were treated with docetaxel or pemetrexed, and the patients in double drug group were treated with docetaxel, pemetrexed, vinorelbine or paclitaxel combined with platinum (cisplatin). The effects of patients in the two groups were compared and the factors affecting the prognosis of the patients were analyzed. ResultsThe remission rate in the double drug group was significantly higher than that in the single drug group (45.0% vs. 20.0%; χ2=4.493, P=0.021). The results of single factor analysis for patients in double drug group showed that pathological type (χ2=7.511, P=0.023), time from firstline treatment to secondline treatment (χ2=6.412, P=0.041), secondline baseline TNM stage (χ2=4.022，P=0.045), secondline cycle number (χ2=5.065，P=0.027), leukopenia (χ2=4.852, P=0.033) and neuron specific enolase (χ2=9.243, P=0.002) were the main prognostic factors of the secondline chemotherapy. The results of multivariate analysis for patients in double drug group showed that time from firstline treatment to secondline treatment (OR=3.511, 95%CI: 1.4863.602, P=0.033), secondline baseline TNM stage (OR=1.623, 95%CI: 1.1272.119, P=0.027), secondline cycle number (OR=2.208, 95%CI: 1.5892.827, P=0.014) and neuron specific enolase (OR=1.960, 95%CI: 1.2092.773, P=0.025) were independent prognostic factors. ConclusionThe remission effect of double secondline treatment scheme based on platinum for patients with NSCLC is good, and the time form firstline treatment to secondline treatment, secondline baseline TNM stage, secondline cycle number and neuron specific enolase are independent prognostic factors. References | Related Articles | Metrics

Expression and clinical significance of pro-gastrin-releasing peptide and carbohydrate antigen 72-4 in patients with gastric cancer LI Li, MENG Hai, ZHAO Guang-Chun, YU Zheng-Qing, YIN Xiao-Dong 2018, 45 (5):  273-276.  doi: 10.3760/cma.j.issn.1673-422X.2018.05.004 Abstract ( 1168 )   PDF (1807KB) ( 538 )   Save ObjectiveTo explore the expressions and clinical values of progastrinreleasing peptide (ProGRP) and carbohydrate antigen 724(CA724) in patients with gastric cancer. MethodsNinety patients with gastric cancer and fifty healthy subjects were selected from January 2014 to December 2016 in our hospital. Serum levels of ProGRP and CA724 were detected by electrochemiluminescence. The relationships between ProGRP and clinicopathological characteristics, postoperative recurrence and CA724 were analyzed. The diagnostic values of ProGRP and CA724 in gastric cancer were analyzed by receiver operating characteristic (ROC) curve. ResultsThe expressions of ProGRP and CA724 in patients with gastric cancer were (249.3±28.9)pg/ml and (148.8±33.5)U/ml respectively, which were significantly higher than those of healthy subjects ［(14.4±7.6)pg/ml and (3.8±1.4)U/ml］, and the differences were statistically sigificant (t=56.320, P＜0.001; t=30.504, P＜0.001). The expression of ProGRP in TNM stage ⅢⅣ ［(269.1±30.9)pg/ml］ was obviously higher than that in stage ⅠⅡ ［(198.5±23.9)pg/ml］, with a significant difference (t=11.200, P＜0.001). The expression of ProGRP in patients with lymph node metastasis ［(259.9±31.4)pg/ml］ was significantly higher than that in patients without lymph node metastasis ［(190.3±26.8)pg/ml］, with a significant difference (t=9.500, P＜0.001). The expression of ProGRP in patients with postoperative recurrence after one year ［(181.3±21.7)pg/ml］ was higer than that in patients without postoperative recurrence ［(26.1±12.8)pg/ml］, with a significant difference (t=31.830, P＜0.001). There was a positive correlation between serum ProGRP and CA724 (r=0.792, P=0.012). According to the ROC curve, the cutoff point of ProGRP was 23.6 pg/ml, and the diagnostic sensitivity was 80.0%, the specificity was 70.0%. The cutoff point of CA724 was 11.2 U/ml, and the diagnostic sensitivity was 60.0%, the specificity was 89.0%. The sensitivity and specificity diagnostic value of combined detection were 89.7% and 94.8%, better than those of individual detection (χ2=6.028, P=0.009; χ2=4.675, P=0.031). ConclusionProGRP and CA724 are highly expressed in the serum of gastric cancer patients, with a positive correlation. The combined detection of ProGRP and CA724 can improve the diagnostic sensitivity and specificity. ProGRP is significantly correlated with tumor stage, lymph node metastasis and prognosis, which may be a mew target for prevention and treatment of gastric cancer. Related Articles | Metrics

Change of HMGB1 expression before and after TACE in patients with hepatocellular carcinoma and its effect on prognosis LU Chang-Yan, WANG Zhong-Hao, ZHANG Hao, LIU Jing-Zhou, XU Hui-Rong, HAN Jian-Jun 2018, 45 (5):  277-280.  doi: 10.3760/cma.j.issn.1673422X.2018.05.005 Abstract ( 517 )   PDF (1787KB) ( 511 )   Save ObjectiveTo observe the change of high mobility group protein B1 (HMGB1) in patients with hepatocellular carcinoma (HCC) before and after transcatheter arterial chemoembolization (TACE) and its effect on prognosis. MethodsA total of 68 HCC patients only with TACE treatment were selected as the research objects from June 2012 to June 2014 in Shandong Tumor Hospital. The serum levels of HMGB1 of all the patients were detected 1 day before TACE and 1 month after TACE. The change of HMGB1 expression before and after TACE was analyzed. According to the reference data, the patients were divided into the highexpression group (≥17.5 ng/ml) and the lowexpression group (<17.5 ng/ml). The shortterm efficacy of the two groups of patients and their survival time were compared. ResultsThe preoperative HMGB1 level of patients was (40.6±13.6)ng/ml, and the 1month postoperative HMGB1 level was (20.1±6.9)ng/ml, and the difference was statistically significant (t=4.22, P=0.040). The effective rate in patients with low HMGB1 expression after TACE was 65.00%, and 39.29% in patients with high HMGB1 expression, with a significant difference (χ2=4.390, P=0.036). The 1, 2, and 3 year survival rates of low HMGB1 expression group were 77.50%, 50.00% and 27.50%, respectively, which were significantly higher than high HMGB1 expression group (57.14%, 21.43% and 7.14%), with a significant difference (χ2=8.301, P=0.040). ConclusionTACE can reduce the HMGB1 expression level in serum of patiens with HCC. The patients with low expression of HMGB1 have the better shortterm efficacy and the longer survival time. Related Articles | Metrics

Coiled coil domain containing 6 and tumor SUN Dan, XIN Yan 2018, 45 (5):  281-284.  doi: 10.3760/cma.j.issn.1673422X.2018.05.006 Abstract ( 536 )   PDF (1899KB) ( 460 )   Save Coiled coil domain containing 6 (CCDC6) is originally found in thyroid papillary carcinoma by participating in RET/PTC1 fusion formation. Studies have shown that CCDC6 plays a vital role in response to DNA damage repair and regulation of cell cycle and apoptosis. As a tumor suppressor, CCDC6 could inhibit tumorgenesis, tumor migration and invasion in thyroid carcinoma, lung cancer, colorectal cancer, prostate cancer and cervical cancer. Intensively study the role and mechanism of CCDC6 in carcinomas will provide a new thought for tumor diagnosis, treatment and clinical prognosis evaluation.   Related Articles | Metrics

Aquaporin 9 and tumor ZHAO Chuan, LIU Fang, WANG Xiu-Yue, CHU Hui-Yuan, CHEN Che 2018, 45 (5):  285-287.  doi: 10.3760/cma.j.issn.1673422X.2018.05.007 Abstract ( 381 )   PDF (1505KB) ( 457 )   Save Molecular Laboratory of Clinical Laboratory Diagnostics, College of Clinical Medical Sciences, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China Related Articles | Metrics

Research advances of alphaenolase in tumors XU Xin, CHEN Bo 2018, 45 (5):  288-291.  doi: 10.3760/cma.j.issn.1673422X.2018.05.008 Abstract ( 591 )   PDF (1912KB) ( 523 )   Save Department of Gastrointestinal Surgery, First Affiliated Hospital of Anhui Medical University， Hefei 230022, China Related Articles | Metrics

Mechanism of microphthalmia family of transcription factors in tumorigenesis ZHUANG Wen-Yuan, GAN Wei-Dong 2018, 45 (5):  292-295.  doi: 10.3760/cma.j.issn.1673422X.2018.05.009 Abstract ( 475 )   PDF (2028KB) ( 412 )   Save Microphthalmia family of transcription factors（MiT/TFE） is very important for the regulation of cancer cell proliferation and energy metabolism. The MiT/TFE promotes the genesis and development of tumors by upregulating the expression of lysosomal genes as well as acting on the oxidative metabolism and the oxidative stress response. MiT/TFE can also regulate lysosomal signaling including the mTORC1 and Wnt/βcatenin pathways. The relationship between MiT/TFE and folliculin (FLCN) is associated with the tumorigenesis. Related Articles | Metrics

Mechanism of myeloid differentiation factor 88 in tumor FAN Yan, XIANG Fen-Fen, CHEN Zi-Xi, KANG Xiang-Dong, WU Rong 2018, 45 (5):  296-299.  doi: 10.3760/cma.j.issn.1673422X.2018.05.010 Abstract ( 410 )   PDF (1953KB) ( 405 )   Save Myeloid differentiation factor 88 (MyD88) plays an important role in tumorigenesis, development and malignant transformation, also participates in the microenvironment, proliferation, apoptosis, invasion, metastasis and tumor resistance. MyD88 may serve as a new and meaningful therapeutic target, which can promote the growth and development of tumors by regulating multiple signaling pathways and enhance the drug resistance of tumor cells. Related Articles | Metrics

Research progress of simvastatin effect on tumor ZHANG Bin, SHI Dong-Mei, QIAO Sen 2018, 45 (5):  300-303.  doi: 10.3760/cma.j.issn.1673422X.2018.05.011 Abstract ( 627 )   PDF (1965KB) ( 518 )   Save Statins can adjust blood fat and cholesterol, and protect the cardiovascular, especially simvastatin, which is used often in clinic. Several recent studies have found that simvastatin can play a positive role in the treatment of multiple tumors by inhibiting tumor growth, invasion and metastasis, and improving the drug resistance of chemotherapeutic agents. Simvastatin may be a potential drug for cancer treatment. It is expected to be a new direction of tumor therapy and prevention. Related Articles | Metrics

Aptamers selection for tumor based on cellSELEX and its application in tumor diagnosis and treatment WANG Jin, WANG Jing, LIAO Shi-Qi, ZENG Jia-Yu 2018, 45 (5):  304-307.  doi: 10.3760/cma.j.issn.1673422X.2018.05.012 Abstract ( 353 )   PDF (2050KB) ( 374 )   Save Aptamers have shown great potential in early diagnosis, treatment of tumor because of its high specificity and affinity. The aptamers selected by cellSELEX can identify tumor cells through target molecular changes, and then realize the prevention and treatment of tumors. At present, researchers have successfully selected a number of aptamers by using cellSELEX technology combined with flow cytometry. To make up for the deficiencies and exert the advantages of aptamers can make aptamer technology really apply to clinical diagnosis and treatment. Related Articles | Metrics

Circular RNA and its application in gynecological carcinoma ZHENG Pan-Chan, SUN Xiao, WANG Li-Hua 2018, 45 (5):  308-311.  doi: 10.3760/cma.j.issn.1673422X.2018.05.013 Abstract ( 475 )   PDF (1855KB) ( 418 )   Save Circular RNAs (circRNAs) are a class of RNA which forms covalently closed loops. They act as microRNA (miRNA) sponge in the circRNAmiRNAmRNA regulatory axis, regulating gene transcription and protein translation. CircRNAs are differently expressed in gynecological carcinoma. They can affect the proliferation, invasion and migration of gynecological tumor cells, playing a role in inhibiting or promoting cancer. CircRNAs are featured with characteristics of  stabilities, abundance, specificity  and conservative, making it a potential target  for the prediction, diagnosis and treatment of gynecologic tumors. Related Articles | Metrics

Relationship between follicular helper T cells and lymphoma YANG Qing-Bo, LIU Fan, YU Jian-Bo 2018, 45 (5):  312-314.  doi: 10.3760/cma.j.issn.1673422X.2018.05.014 Abstract ( 640 )   PDF (1308KB) ( 536 )   Save The follicular helper T cell (TFh) is a new subset of CD4+ helper T cells discovered in recent studies. Studies have shown that it  is associated with diseases such as immune diseases, immunodeficiency and poor prognosis of patients with lymphoma. At the same time, there is a close relationship between TFh cells and some nonspecific T cell lymphomas. However, the role of TFh cells in the tumor microenvironment needs to be further studied.   Related Articles | Metrics