Journal of International Oncology ›› 2018, Vol. 45 ›› Issue (5): 296-299.doi: 10.3760/cma.j.issn.1673422X.2018.05.010

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Mechanism of myeloid differentiation factor 88 in tumor

Fan Yan, Xiang Fenfen, Chen Zixi, Kang Xiangdong, Wu Rong   

  1.  Department of Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200333, China
  • Online:2018-05-08 Published:2018-05-23
  • Contact: Wu Rong E-mail:rong701@126.com
  • Supported by:

    National Natural Science Foundation of China (81703878)

Abstract: Myeloid differentiation factor 88 (MyD88) plays an important role in tumorigenesis, development and malignant transformation, also participates in the microenvironment, proliferation, apoptosis, invasion, metastasis and tumor resistance. MyD88 may serve as a new and meaningful therapeutic target, which can promote the growth and development of tumors by regulating multiple signaling pathways and enhance the drug resistance of tumor cells.

Key words: Neoplasms, Myeloid differentiation factor 88