Mechanisms of FOXM1 in carcinogenesis and the progression of the antiFOXM1 target drugs

doi:10.3760/cma.j.issn.1673422X.2016.04.009

Journal of International Oncology ›› 2016, Vol. 43 ›› Issue (4): 274-277.doi: 10.3760/cma.j.issn.1673422X.2016.04.009

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Mechanisms of FOXM1 in carcinogenesis and the progression of the antiFOXM1 target drugs

Tian Chuan, Li Qi

Department of Oncology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China

Online:2016-04-08 Published:2016-03-02
Contact: Li Qi E-mail:leeqi2001@hotmail.com
Supported by:
National Natural Science Foundation of China(81272714)； Funded by Key Disciplines Group Construction Project of Pudong Health Bureau of Shanghai（PWZxq201404）

Abstract

Abstract: Forkhead box M1 (FOXM1)， one member of the Forkhead family， plays an important role in tumor development, invasion, metastasis and angiogenesis by regulating the expression of tumor related genes. Moreover, The specific mechanism of FOXM1 is not fully understood in the development of tumors. Currently，the study of anticancer drugs targeting FOXM1 is in the initial stage. Exploring the mechanism of FOXM1 in carcinogenesis and the development of drugs targeting FOXM1 and its downstream signaling pathways have broad clinical application prospects.

Key words: Forkhead transcription factors, Neoplasms, Antitumor drugs

TIAN Chuan, LI Qi. Mechanisms of FOXM1 in carcinogenesis and the progression of the antiFOXM1 target drugs[J]. Journal of International Oncology, 2016, 43(4): 274-277.

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Mechanisms of FOXM1 in carcinogenesis and the progression of the antiFOXM1 target drugs

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