Voltagegated potassium channel Kv1.5 and cancer

Abstract

Abstract: The voltagegated potassium channels Kv1.5 is widely expressed in the plasma membranes of numerous tumor cells and it can contribute to a variety of cellular functions such as proliferation， apoptosis, and cell cycle. Several types of antineoplastic drugs can change the expression of Kv1.5 and then affect the biological processes. Kv1.5 is identified as a novel target for therapy in human cancer. The researches of Kv1.5 will contribute to gain a further understanding of the molecular mechanism of tumor and provide therapeutic opportunity for the prevention and treatment of cancer.

Key words: Neoplasms, Antineoplastic agents, Kv1.5 potassium channels

CHEN Zhi-Da, ZENG Wen-Rong, LIN Bin, WU Xin-Yu, WU Jin. Voltagegated potassium channel Kv1.5 and cancer[J]. Journal of International Oncology, 2016, 43(2): 130-.

References

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