Abstract: JAK/STAT pathway is a central signaling activated by cytokines binding with their relative receptors which can regulate cell proliferation, differentiation and apoptosis. Recent studies have suggested that abnormal signaling pathway with gene mutation and dysregulation plays an important part in the pathogenesis and progression of acute leukemia. Increasing investigation of this pathway may provide novel target therapies.

Key words: font-size: 12pt, mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 宋体" lang="EN-US">Acute leukemia, Therapy, JAK/STAT pathway