Abstract: Chemokines are major regulators of cell transformation and adhesion. Recent study has demonstrated that CXCR7 can bind to CXCL11 and CXCL12 with high affinity, and the activated CXCR7 may influence tumor invasion and metastasis by regulating extracellular matrix (ECM) and epithelial-mesenchymal transition (EMT) and other signal transduction pathways. Therefore, in-depth study of  the molecular mechanisms between CXCR7 and tumor invasion and metastasis may provide a more effective theoretical basis for tumor treatment.

Key words: CXCR7, Neoplasms, Extracellular matrix, Epithelial-mesenchymal transition