Journal of International Oncology ›› 2013, Vol. 40 ›› Issue (8): 668-670.

Previous Articles     Next Articles

Wnt/β-catenin signaling pathway and glioma

CHEN  Meng-Na, LIU  Ting, GUO  Geng   

  1. First Clinical Medical College, Shanxi Medical University, Taiyuan 030001, China

  • Online:2013-09-08 Published:2013-09-16
  • Contact: Corresponding author: GUO Geng, E-mail: guogeng973@163.com E-mail:guogeng973@163.com

Abstract: Wnt/β-catenin signaling pathway is highly conserved in evolution, which involves in the regulation of a variety of biological processes such as embryonic growth, development, energy metabolism and stem cells maintenance. Aberrant activation of Wnt/β-catenin signaling pathway has a closely relationship with tumorigenesis. Investigating the role of Wnt/β-catenin signaling in glioma cell proliferation, invasion, apoptosis and tumor angiogenesis will provide novel therapeutic targets and intervening measures for glioma treatment.

Key words: Glioma, Cell proliferation, Neoplasm invasiveness, Apoptosis, Wnt∕β-catenin signaling pathway