Abstract: SOX1, a member of the SOX transcript factor super family, has been demonstrated having the functions of regulating the development of human embryonic neural system and crystalline lens, and the additional function of SOX1 in tumors are attracting more and more attention as well. It is reported in resent years that SOX1 is detected low expressed in many kinds of tumor issue, which owns to the methylation of SOX1. SOX1 can also regulate the abilities of tumors on proliferation, invasion and migration. Besides, SOX1 may play a crucial role in regulation of the differentiation of cancer stem cells. Further research of SOX1 and its function among related pathways may contribute to seeking for new therapies for tumor treatment.

Key words: Neoplasms, SOX1 protein