Research progress of NADPH oxidase 2 in malignant tumors

doi:10.3760/cma.j.cn371439-20230428-00117

Abstract

Abstract:

Reduced nicotinamide adenine dinucleotide phosphate （NADPH） oxidase 2 （Nox2） acts as a source of reactive oxygen species， which participates in and influences normal physiological function of human body. Nowadays， many studies have found that Nox2 is related to prognosis of patients， drug resistance and molecular targeted therapy in various malignant tumors， such as acute myeloid leukemia， gastric cancer， colorectal cancer， ovarian cancer， lung cancer and esophageal cancer. What's more， it may be a novel biomarker and a potential therapeutic target for malignant tumors.

Key words: NADPH oxidase 2, Neoplasms, Reactive oxygen species, Drug resistance， neoplasm, Prognosis

Liu Xiaojie, Huang Junxing. Research progress of NADPH oxidase 2 in malignant tumors[J]. Journal of International Oncology, 2023, 50(10): 618-621.

References 30

[1]	Grauers Wiktorin H, Aydin E, Hellstrand K, et al. NOX2-derived reactive oxygen species in cancer[J]. Oxid Med Cell Longev, 2020: 7095902. DOI: 10.1155/2020/7095902.
[2]	Schröder K. NADPH oxidases: current aspects and tools[J]. Redox Biol, 2020, 34: 101512. DOI: 10.1016/j.redox.2020.101512.
[3]	Vermot A, Petit-Härtlein I, Smith SME, et al. NADPH oxidases (NOX): an overview from discovery, molecular mechanisms to physiology and pathology[J]. Antioxidants (Basel), 2021, 10(6): 890. DOI: 10.3390/antiox10060890.
[4]	Xu L, Balzarolo M, Robinson EL, et al. NOX1 mediates metabolic heart disease in mice and is upregulated in monocytes of humans with diastolic dysfunction[J]. Cardiovasc Res, 2022, 118(14): 2973-2984. DOI: 10.1093/cvr/cvab349.
[5]	Mohri H, Ninoyu Y, Sakaguchi H, et al. Nox3-derived superoxide in cochleae induces sensorineural hearing loss[J]. J Neurosci, 2021, 41(21): 4716-4731. DOI: 10.1523/JNEUROSCI.2672-20.2021.
[6]	Trevelin SC, Shah AM, Lombardi G. Beyond bacterial killing: NADPH oxidase 2 is an immunomodulator[J]. Immunol Lett, 2020, 221: 39-48. DOI: 10.1016/j.imlet.2020.02.009. pmid: 32092360
[7]	Shimony S, Stahl M, Stone RM. Acute myeloid leukemia: 2023 update on diagnosis, risk-stratification, and management[J]. Am J Hematol, 2023, 98(3): 502-526. DOI: 10.1002/ajh.26822. pmid: 36594187
[8]	Jones CL. NOX2: a determinant of acute myeloid leukemia survival[J]. Haematologica, 2022, 107(11): 2530-2531. DOI: 10.3324/haematol.2022.280677.
[9]	Paolillo R, Boulanger M, Gâtel P, et al. The NADPH oxidase NOX2 is a marker of adverse prognosis involved in chemoresistance of acute myeloid leukemias[J]. Haematologica, 2022, 107(11): 2562-2575. DOI: 10.3324/haematol.2021.279889. pmid: 35172562
[10]	Ijurko C, González-García N, Galindo-Villardón P, et al. A 29-gene signature associated with NOX2 discriminates acute myeloid leukemia prognosis and survival[J]. Am J Hematol, 2022, 97(4): 448-457. DOI: 10.1002/ajh.26477. pmid: 35073432
[11]	Robinson AJ, Hopkins GL, Rastogi N, et al. Reactive oxygen species drive proliferation in acute myeloid leukemia via the glycolytic regulator PFKFB3[J]. Cancer Res, 2020, 80(5): 937-949. DOI: 10.1158/0008-5472.CAN-19-1920. pmid: 31862780
[12]	Germon ZP, Sillar JR, Mannan A, et al. Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies[J]. Sci Signal, 2023, 16(778): eabp9586. DOI: 10.1126/scisignal.abp9586.
[13]	Cao JY, Mansouri S, Frappier L. Changes in the nasopharyngeal carcinoma nuclear proteome induced by the EBNA1 protein of Epstein-Barr virus reveal potential roles for EBNA1 in metastasis and oxidative stress responses[J]. J Virol, 2012, 86(1): 382-394. DOI: 10.1128/JVI.05648-11. pmid: 22013061
[14]	Kim SM, Hur DY, Hong SW, et al. EBV-encoded EBNA1 regulates cell viability by modulating miR34a-NOX2-ROS signaling in gastric cancer cells[J]. Biochem Biophys Res Commun, 2017, 494(3/4): 550-555. DOI: 10.1016/j.bbrc.2017.10.095.
[15]	Wang P, Shi Q, Deng WH, et al. Relationship between expression of NADPH oxidase 2 and invasion and prognosis of human gastric cancer[J]. World J Gastroenterol, 2015, 21(20): 6271-6279. DOI: 10.3748/wjg.v21.i20.6271.
[16]	Wang Z, Tang T, Wang S, et al. Aloin inhibits the proliferation and migration of gastric cancer cells by regulating NOX2-ROS-mediated pro-survival signal pathways[J]. Drug Des Devel Ther, 2020, 14: 145-155. DOI: 10.2147/DDDT.S219247.
[17]	You X, Ma M, Hou G, et al. Gene expression and prognosis of NOX family members in gastric cancer[J]. Onco Targets Ther, 2018, 11: 3065-3074. DOI: 10.2147/OTT.S161287.
[18]	Luo M, Yang X, Chen HN, et al. Drug resistance in colorectal cancer: an epigenetic overview[J]. Biochim Biophys Acta Rev Cancer, 2021, 1876(2): 188623. DOI: 10.1016/j.bbcan.2021.188623.
[19]	Banskota S, Regmi SC, Kim JA. NOX1 to NOX2 Switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7[J]. Mol Cancer, 2015, 14: 123. DOI: 10.1186/s12943-015-0379-0. pmid: 26116564
[20]	Takiguchi K, Shimizu H, Shoda K, et al. The expression and role of NADPH oxidase 2 in colon cancer[J]. Anticancer Res, 2023, 43(6): 2601-2608. DOI: 10.21873/anticanres.16427. pmid: 37247898
[21]	Guo Y, Han B, Luo K, et al. NOX2-ROS-HIF-1α signaling is critical for the inhibitory effect of oleanolic acid on rectal cancer cell proliferation[J]. Biomed Pharmacother, 2017, 85: 733-739. DOI: 10.1016/j.biopha.2016.11.091. pmid: 27938946
[22]	Waghela BN, Vaidya FU, Pathak C. Upregulation of NOX-2 and Nrf-2 promotes 5-fluorouracil resistance of human colon carcinoma (HCT-116) cells[J]. Biochemistry (Mosc), 2021, 86(3): 262-274. DOI: 10.1134/S0006297921030044. pmid: 33838628
[23]	Yang WH, Huang Z, Wu J, et al. A TAZ-ANGPTL4-NOX2 axis regulates ferroptotic cell death and chemoresistance in epithelial ovarian cancer[J]. Mol Cancer Res, 2020, 18(1): 79-90. DOI: 10.1158/1541-7786.MCR-19-0691.
[24]	Yang WH, Chi JT. Hippo pathway effectors YAP/TAZ as novel determinants of ferroptosis[J]. Mol Cell Oncol, 2019, 7(1): 1699375. DOI: 10.1080/23723556.2019.1699375.
[25]	Wang N, Song L, Xu Y, et al. Loss of scribble confers cisplatin resistance during NSCLC chemotherapy via Nox2/ROS and Nrf2/PD-L1 signaling[J]. EBioMedicine, 2019, 47: 65-77. DOI: 10.1016/j.ebiom.2019.08.057. pmid: 31495720
[26]	Zhan Y, Chen Q, Song Y, et al. Berbamine hydrochloride inhibits lysosomal acidification by activating Nox2 to potentiate chemotherapy-induced apoptosis via the ROS-MAPK pathway in human lung carcinoma cells[J]. Cell Biol Toxicol, 2023, 39(4): 1297-1317. DOI: 10.1007/s10565-022-09756-8.
[27]	Zhao L, Chen X, Feng Y, et al. COX7A1 suppresses the viability of human non-small cell lung cancer cells via regulating autophagy[J]. Cancer Med, 2019, 8(18): 7762-7773. DOI: 10.1002/cam4.2659.
[28]	Liu Y, Han D, Ma Q, et al. Prognostic value of NOX2 as a potential biomarker for lung adenocarcinoma using TCGA and clinical validation[J]. Mol Med Rep, 2023, 27(2): 48. DOI: 10.3892/mmr.2023.12935.
[29]	Shimizu H, Katsurahara K, Inoue H, et al. NADPH oxidase 2 has a crucial role in cell cycle progression of esophageal squamous cell carcinoma[J]. Ann Surg Oncol, 2022, 29(13): 8677-8687. DOI: 10.1245/s10434-022-12384-5.
[30]	Hu Y, Ye X, Wang R, et al. Current research progress in the role of reactive oxygen species in esophageal adenocarcinoma[J]. Transl Cancer Res, 2021, 10(3): 1568-1577. DOI: 10.21037/tcr-19-1985. pmid: 35116481