Research progress of memantine hydrochloride in the treatment of radiation-induced cognitive dysfunction and its combined application with vitamins

doi:10.3760/cma.j.cn371439-20230418-00118

Abstract

Abstract:

Radiation-induced cognitive dysfunction （RICD） has an insidious onset and there is a lack of effective prevention and treatment measures. The efficacy of memantine hydrochloride as a classical treatment drug is limited， and it is inevitable to seek multi-target combination drugs. In recent years， the protective effect of vitamin E and vitamin D on cognitive function has been widely recognized. Several basic studies have shown that vitamin E can play a role in the combination of medication by protecting neurons and reducing the adverse effects caused by memantine hydrochloride； Vitamin D and memantine hydrochloride have also become a hot topic of research due to their significant synergistic effects. The combination of memantine hydrochloride and vitamin therapy is expected to bring additional benefits to RICD patients.

Key words: Radiotherapy, Cognitive dysfunction, Memantine, Vitamins

Wang Jin, Li Ruoyang, Zhao Xuewei, Li Hui, Zhou Zhiguo, Zhao Jingxia. Research progress of memantine hydrochloride in the treatment of radiation-induced cognitive dysfunction and its combined application with vitamins[J]. Journal of International Oncology, 2023, 50(10): 622-626.

References 38

[1]	Haldbo-Classen L, Amidi A, Wu LM, et al. Long-term cognitive dysfunction after radiation therapy for primary brain tumors[J]. Acta Oncol, 2019, 58(5): 745-752. DOI: 10.1080/0284186X.2018.1557786. pmid: 30757955
[2]	Turnquist C, Harris BT, Harris CC. Radiation-induced brain injury: current concepts and therapeutic strategies targeting neuroinflammation[J]. Neurooncol Adv, 2020, 2(1): vdaa057. DOI: 10.1093/noajnl/vdaa057.
[3]	彭雯硕, 陈乃耀, 胡霞, 等. 脑部放疗引起认知功能障碍的预防和治疗[J]. 国际肿瘤学杂志, 2021, 48(1): 52-56. DOI: 10.3760/cma.j.cn371439-20200810-00010.
[4]	Scampoli C, Cammelli S, Galietta E, et al. Memantine in the prevention of radiation-induced brain damage: a narrative review[J]. Cancers (Basel), 2022, 14(11): 2736. DOI: 10.3390/cancers14112736.
[5]	Duman JG, Dinh J, Zhou W, et al. Memantine prevents acute radiation-induced toxicities at hippocampal excitatory synapses[J]. Neuro Oncol, 2018, 20(5): 655-665. DOI: 10.1093/neuonc/nox203.
[6]	Bálentová S, Adamkov M. Pathological changes in the central nervous system following exposure to ionizing radiation[J]. Physiol Res, 2020, 69(3): 389-404. DOI: 10.33549/physiolres.934309. pmid: 32469226
[7]	Moretti R, Caruso P. An iatrogenic model of brain small-vessel disease: post-radiation encephalopathy[J]. Int J Mol Sci, 2020, 21(18): 6506. DOI: 10.3390/ijms21186506.
[8]	Brown PD, Pugh S, Laack NN, et al. Memantine for the prevention of cognitive dysfunction in patients receiving whole-brain radiotherapy: a randomized, double-blind, placebo-controlled trial[J]. Neuro Oncol, 2013, 15(10): 1429-1437. DOI: 10.1093/neuonc/not114.
[9]	Lynch M. Preservation of cognitive function following whole brain radiotherapy in patients with brain metastases: complications, treatments, and the emerging role of memantine[J]. J Oncol Pharm Pract, 2019, 25(3): 657-662. DOI: 10.1177/1078155218798176. pmid: 30200844
[10]	Laack NN, Pugh SL, Brown PD, et al. The association of health-related quality of life and cognitive function in patients receiving memantine for the prevention of cognitive dysfunction during whole-brain radiotherapy[J]. Neurooncol Pract, 2019, 6(4): 274-282. DOI: 10.1093/nop/npy038. pmid: 31386073
[11]	Brown PD, Gondi V, Pugh S, et al. Hippocampal avoidance during whole-brain radiotherapy plus memantine for patients with brain metastases: phase Ⅲ trial NRG oncology CC001[J]. J Clin Oncol, 2020, 38(10): 1019-1029. DOI: 10.1200/JCO.19.02767. pmid: 32058845
[12]	Gondi V, Pugh SL, Mehta MP, et al. NRG oncology CC003: a randomized phase Ⅱ/Ⅲ trial of prophylactic cranial irradiation with or without hippocampal avoidance for small cell lung cancer[J]. J Clin Oncol, 2019, 37(15_suppl): TPS8578. DOI: 10.1200/JCO.2019.37.15_suppl.TPS8578.
[13]	Bhanu A, Waghmare CM, Jain VS, et al. Serum 25-hydroxy vitamin-D levels in head and neck cancer chemoradiation therapy: potential in cancer therapeutics[J/OL]. Indian J Cancer. (2023-02-27)[2023-04-10]. https://pubmed.ncbi.nlm.nih.gov/36861720/. DOI: 10.4103/ijc.IJC_358_20.
[14]	Sudmeier L, Switchenko J, Eaton B, et al. RTHP-01. Pentoxifylline and vitamin E for the treatment of radiation necrosis after stereotactic radiosurgery[J]. Neuro Oncol, 2019, 21(Supplement_6): vi210. DOI: 10.1093/neuonc/noz175.874.
[15]	Ji MT, Nie J, Nie XF, et al. 1α,25(OH)₂D₃ radiosensitizes cancer cells by activating the NADPH/ROS pathway[J]. Front Pharmacol, 2020, 11: 945. DOI: 10.3389/fphar.2020.00945.
[16]	Chen PT, Hsieh CC, Chen MF. Role of vitamin D₃ in tumor aggressiveness and radiation response for hepatocellular carcinoma[J]. Mol Carcinog, 2022, 61(8): 787-796. DOI: 10.1002/mc.23421.
[17]	Gu YH, Kang KM, Yamashita T, et al. Effects of vitamin E on the immune system and tumor growth during radiotherapy[J]. J Cancer Res Ther, 2021, 17(1): 211-217. DOI: 10.4103/jcrt.JCRT_706_18.
[18]	Jung AY, Cai X, Thoene K, et al. Antioxidant supplementation and breast cancer prognosis in postmenopausal women undergoing chemotherapy and radiation therapy[J]. Am J Clin Nutr, 2019, 109(1): 69-78. DOI: 10.1093/ajcn/nqy223. pmid: 30668630
[19]	Day NL, Carle MS, Floyd CL. Post-injury administration of a combination of memantine and 17β-estradiol is protective in a rat model of traumatic brain injury[J]. Neurochem Int, 2017, 111: 57-68. DOI: 10.1016/j.neuint.2017.04.018. pmid: 28472639
[20]	Lamprecht MR, Morrison B 3rd. A combination therapy of 17β-estradiol and memantine is more neuroprotective than monotherapies in an organotypic brain slice culture model of traumatic brain injury[J]. J Neurotrauma, 2015, 32(17): 1361-1368. DOI: 10.1089/neu.2015.3912.
[21]	Dysken MW, Sano M, Asthana S, et al. Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial[J]. JAMA, 2014, 311(1): 33-44. DOI: 10.1001/jama.2013.282834. pmid: 24381967
[22]	Annweiler C, Brugg B, Peyrin JM, et al. Combination of memantine and vitamin D prevents axon degeneration induced by amyloid-β and glutamate[J]. Neurobiol Aging, 2014, 35(2): 331-335. DOI: 10.1016/j.neurobiolaging.2013.07.029. pmid: 24011542
[23]	Broberg DN, Wong D, Bellyou M, et al. Effects of memantine and high dose vitamin D on gait in male APP/PS1 Alzheimer's disease mice following vitamin D deprivation[J]. J Alzheimers Dis, 2022, 85(4): 1755-1766. DOI: 10.3233/JAD-215188.
[24]	Zamani N, Moazedi AA. The effects of co-administration of memantine and vitamin D on spatial learning and memory impairment in adult male rats model of Alzheimer's disease[J]. J Arak Univ Med Sci, 2020, 22(6): 192-203. DOI: 10.32598/jams.22.6.5166.2.
[25]	Wong D, Broberg DN, Doad J, et al. Effect of memantine treatment and combination with vitamin D supplementation on body composition in the APP/PS1 mouse model of Alzheimer's disease following chronic vitamin D deficiency[J]. J Alzheimers Dis, 2021, 81(1): 375-388. DOI: 10.3233/JAD-201137.
[26]	Lemire P, Brangier A, Beaudenon M, et al. Cognitive changes under memantine according to vitamin D status in Alzheimer patients: an exposed/unexposed cohort pilot study[J]. J Steroid Biochem Mol Biol, 2018, 175: 151-156. DOI: 10.1016/j.jsbmb.2016.12.019.
[27]	Annweiler C, Herrmann FR, Fantino B, et al. Effectiveness of the combination of memantine plus vitamin D on cognition in patients with Alzheimer disease: a pre-post pilot study[J]. Cogn Behav Neurol, 2012, 25(3): 121-127. DOI: 10.1097/WNN.0b013e31826df647. pmid: 22960436
[28]	Lecoq AL, Livrozet M, Blanchard A, et al. Drug-related hypercalcemia[J]. Endocrinol Metab Clin North Am, 2021, 50(4): 743-752. DOI: 10.1016/j.ecl.2021.08.001.
[29]	Aqeel F, Del Castillo J, Jaar BG, et al. Hypercalcemia, acute kidney injury, and metabolic alkalosis[J]. Case Rep Nephrol, 2022, 2022: 1320259. DOI: 10.1155/2022/1320259.
[30]	Barth K, Sedivy M, Lindner G, et al. Successful treatment with denosumab for two cases with hypercalcemia due to vitamin D intoxication and associated acute kidney injury[J]. CEN Case Rep, 2022, 11(1): 141-145. DOI: 10.1007/s13730-021-00643-5.
[31]	Jia J, Hu J, Huo X, et al. Effects of vitamin D supplementation on cognitive function and blood Aβ-related biomarkers in older adults with Alzheimer's disease: a randomised, double-blind, placebo-controlled trial[J]. J Neurol Neurosurg Psychiatry, 2019, 90(12): 1347-1352. DOI: 10.1136/jnnp-2018-320199. pmid: 31296588
[32]	Schietzel S, Fischer K, Brugger P, et al. Effect of 2 000 IU compared with 800 IU vitamin D on cognitive performance among adults age 60 years and older: a randomized controlled trial[J]. Am J Clin Nutr, 2019, 110(1): 246-253. DOI: 10.1093/ajcn/nqz081. pmid: 31152541
[33]	Castle M, Fiedler N, Pop LC, et al. Three doses of vitamin D and cognitive outcomes in older women: a double-blind randomized controlled trial[J]. J Gerontol A Biol Sci Med Sci, 2020, 75(5): 835-842. DOI: 10.1093/gerona/glz041.
[34]	Mohammad LG. Two immigrant children with vitamin D poisoning[J]. Ugeskr Laeger, 2018, 180(26): V12170921.
[35]	Zajac IT, Barnes M, Cavuoto P, et al. The effects of vitamin D-enriched mushrooms and vitamin D₃ on cognitive performance and mood in healthy elderly adults: a randomised, double-blinded, placebo-controlled trial[J]. Nutrients, 2020, 12(12): 3847. DOI: 10.3390/nu12123847.
[36]	Kang JH, Vyas CM, Okereke OI, et al. Effect of vitamin D on cognitive decline: results from two ancillary studies of the VITAL randomized trial[J]. Sci Rep, 2021, 11(1): 23253. DOI: 10.1038/s41598-021-02485-8. pmid: 34853363
[37]	Mäkitie A, Tuokkola I, Laurell G, et al. Vitamin D in head and neck cancer: a systematic review[J]. Curr Oncol Rep, 2020, 23(1): 5. DOI: 10.1007/s11912-020-00996-7. pmid: 33216252
[38]	Liang L, Yu W, Cai B, et al. Determination of multiple vitamins in 178 patients undergoing chemotherapy for lung cancer[J/OL]. Arch Med Sci. (2021-01-11)[2023-04-10]. https://doi.org/10.5114/aoms/130302. DOI: 10.5114/aoms/130302.