Role of LHPP in malignant tumor

doi:10.3760/cma.j.cn371439-20200630-00080

Abstract

Abstract:

Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) is a highly conserved histidine phosphatase from worms to humans in evolution. Recent studies have shown that LHPP, as a tumor suppressor, can inhibit the proliferation, growth and migration of the cells and promote apoptosis by participating in the regulation of various cell signaling pathways and protein phosphorylation. Therefore, the deeply study on the mechanism of LHPP is helpful to explore the best diagnostic markers and therapeutic targets for related tumors, which is essential for improving the prognosis of related tumors.

Key words: Neoplasms, Phosphatidylinositol 3-kinase, Prognosis, LHPP

Li Tiantian, Chen Min, Liu Yichen, Peng Jie, Shi Xiaofeng. Role of LHPP in malignant tumor[J]. Journal of International Oncology, 2021, 48(7): 420-423.

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