Mechanism of anti-tumor effect of dihydroartemisinin

doi:10.3760/cma.j.issn.1673-422X.2017.06.012

Abstract

Abstract: Dihydroartemisinin (DHA), the major active metabolite of artemisinin, participates in tumor progression through the following ways: forming free radicals to induce cancer cells death dependent on iron, inducing apoptosis, inhibiting angiogenesis, tumor cells invasion and metastasis, modulating multidrug resistance, controlling intracellular Ca2+ concentration, regulating cell cycles, cell autophagy and the immune system and so on. Generally, it is considered to be a potential antitumor drug.

Key words: Artemisinins, Neoplasms, Apoptosis, Cell proliferation, Dihydroartemisinin

Peng Wenmiao, Fu Hongxing, Yu Lifang, Rao Zhiguo. Mechanism of anti-tumor effect of dihydroartemisinin[J]. Journal of International Oncology, 2017, 44(6): 448-.

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