Journal of International Oncology

Journal of International Oncology ›› 2017, Vol. 44 ›› Issue (2): 122-124.doi: 10.3760/cma.j.issn.1673422X.2017.01.011

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The role of garlic allyl sulfide in malignant tumor

Chen Xueyan, Xiong Ting, Liu Xiaowang, Chen Xiaoxiao, Li Liding, Tian Wen, Xie Weiquan, Tu Jian   

  1. Institute of Pharmacy & Pharmacology, University of South China, Hengyang 421001, China
  • Online:2017-02-08 Published:2017-01-04
  • Contact: Tu Jian E-mail:tujian0734@aliyun.com
  • Supported by:

    National Natural Science Foundation of China (81541163); Natural Science Foundation of Hunan Province of China (2015JJ3101); the Open Fund Based on Innovation Platform of Hunan Provincial Education Department (15K111); Hunan Provincial Cooperative Innovation Center for Molecular Target New Drug Study (2014405); Innovation Program of College in Cooperative Innovation Center for Molecular Target New Drug of University of South China (0223000200021); College Students′ Innovative Project of University of South China (2016NH049XJXZ)

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Abstract: A large number of epidemiological studies have showed that garlic could reduce the incidence and mortality rates of variety cancers such as colon cancer, prostate cancer, stomach cancer, and so on. The main effective anticancer component in garlic was allyl sulfide. Its anticancer mechanisms included regulating signal transduction pathways, blocking the cell cycle, inducing apoptosis and differentiation of the tumor and inhibiting the expressions of oncogenes and so on.

Key words: Garlic, Neoplasms, Allyl sulfide, Diallyl disulfide, Diallyl trisulfide