Journal of International Oncology

Journal of International Oncology ›› 2017, Vol. 44 ›› Issue (2): 108-111.doi: 10.3760/cma.j.issn.1673422X.2017.02.007

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Advances of long non-coding RNA UCA1 in cancers

Yan Dali, Cao Haixia, Feng Jifeng   

  1. Fourth Clinical Medical College of Nanjing Medical University; Department of Medical Oncology, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing 210009,China
  • Online:2017-02-08 Published:2017-01-04
  • Contact: Feng Jifeng E-mail:jifeng_feng@163.com
  • Supported by:

    National Natural Science Foundation of China (81372396); Natural Science Foundation of Jiangsu Province of China (BK20141016)

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Abstract: Long non-coding RNA  urothelial carcinoma associated 1 (UCA1) is initially discovered and named in bladder cancer tissue,  which is highly expressed in multi types of tumor tissues, such as bladder cancer, ovarian cancer, lung cancer, suggesting that UCA1 acts as oncogene. UCA1 is confirmed to regulate tumor cell proliferation, apoptosis, invasion and migration, which plays an important role in the occurrence and development of cancers. UCA1 is expected to become a new biomarker for diagnosis, prognosis and drug susceptibility, which may be a promising therapeutic target of cancer.

Key words: Neoplasms, Protooncogenes, Urothelial carcinoma associated Neoplasms, Proto-oncogenes, Urothelial carcinoma associated 1