Nucleic acid aptamer and its research progress in glioma

doi:10.3760/cma.j.issn.1673-422X.2017.01.010

Journal of International Oncology ›› 2017, Vol. 44 ›› Issue (1): 38-40.doi: 10.3760/cma.j.issn.1673-422X.2017.01.010

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Nucleic acid aptamer and its research progress in glioma

Kou Zhewen, Peng Li, Zhang Xingmei

Department of Neurobiology, School of Basic Medical Science, Southern Medical University, Guangzhou 510515, China

Online:2017-01-08 Published:2016-12-07
Contact: Zhang Xingmei, Email: zxmray@hotmail.com E-mail:zxmray@hotmail.com
Supported by:
National Natural Science Foundation of China (81272509, 30973481)

Abstract

Abstract: Nucleic acid aptamer is an oligonucleotide generated by the systematic evolution of ligands by exponential enrichment (SELEX) process from oligonucleotide library. Nucleic acid aptamer can bind to various targets with high specificity and can recognize or inhibit the biological activity of targeting molecular. Gliomaspecific aptamers are developed by either targeting the glioma cells or known biomarkers, which can be coupled with nanoparticles, drugs or molecular probes, and can be applied in the imaging, targeted therapy and drug delivery of glioma.

Key words: Glioma, Aptamers, nucleotide

Kou Zhewen, Peng Li, Zhang Xingmei. Nucleic acid aptamer and its research progress in glioma[J]. Journal of International Oncology, 2017, 44(1): 38-40.

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Nucleic acid aptamer and its research progress in glioma

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