Aptamers as molecular probes in tumor molecular imaging

doi:10.3760/cma.j.issn.1673-422X.2016.11.009

Abstract

Abstract: The ideal molecular imaging probe should have characteristics of specificity, sensitivity and safety. Aptamers are singstrand DNA or RNA oligonucleotides which can bind their targets with high specificity and high affinity. Aptamers are new types of molecular imaging probe because they have many advantages, such as their large sum of possible targets, small molecule weights, easily production and modification, low immunogenicity, high tissue penetration and so on. Now more and more aptamers research on tumor molecular imaging provides a new technology and tool for tumor diagnosis and therapy.

Key words: Molecular probes, Aptamers, nucleotide, Neoplasms

Shi Yusheng, Peng Yonghua, Sheng Shuyue, Zhang Xingmei. Aptamers as molecular probes in tumor molecular imaging[J]. Journal of International Oncology, 2016, 43(11): 838-840.

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