Journal of International Oncology ›› 2016, Vol. 43 ›› Issue (11): 835-837.doi: 10.3760/cma.j.issn.1673-422X.2016.11.008

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Research of ribomomal protein L23 in tumor progression

Peng Wenmiao, Qin Chuanrong, Zhang Zhimin, Hu Meng, Rao Zhiguo   

  1. epartment of Oncology, Wuhan General Hospital of Guangzhou Military Command, Wuhan 430070, China
  • Received:2016-05-13 Online:2016-11-08 Published:2016-11-02
  • Contact: Rao Zhiguo E-mail:raozhiguo@hotmail.com
  • Supported by:

    Natural Science Foundation of Hubei Province of China (2014CFC1049)

Abstract: Ribosomal protein L23 is a new target for gene therapy of cancer. It participates in tumor progression by activating p53, inactivating murine double minute 2, regulating the carcinogenic activity of cMyc, inducing the multidrug resistance, and affecting the biologic behaviour of tumors. Generally, it′s considered to be a potential prognostic factor in human cancers.

Key words: Neoplasms, Genes, p53, Genes, myc, Drug resistance,multiple, Ribosomal protein L23