Mechanism of action and clinical significance of circular RNA in triple negative breast cancer

doi:10.3760/cma.j.cn371439-20240702-00131

Abstract

Abstract:

Circular RNA （circRNA） has shown great application potential in triple-negative breast cancer （TNBC）. The aberrantly expressed circRNAs participate in the occurrence and development of TNBC by acting as microRNA sponges， regulating gene expression， interacting with functional proteins， and encoding short peptides or proteins to regulate the biological processes of TNBC cell proliferation， apoptosis， invasion， metastasis， and drug resistance. circRNAs are emerging biomarkers for early diagnosis and prognosis of TNBC， as well as new therapeutic targets with potential clinical value. Further elucidation of the complex mechanism of circRNAs in TNBC may provide an important theoretical basis for the development of precise therapeutic strategies for TNBC.

Key words: Triple negative breast neoplasms, RNA， circular, Carcinogenesis, Biological therapy

Wang Li, Xiao Han, Huang Guofu. Mechanism of action and clinical significance of circular RNA in triple negative breast cancer[J]. Journal of International Oncology, 2024, 51(12): 774-778.

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