Roles of AGGF1 in tumor and its regulatory mechanisms

doi:10.3760/cma.j.issn.1673-422X.2019.03.007

Abstract

Abstract: Angiogenic factor with G and FHA domain 1 (AGGF1) is an identified angiogenic factor in recent years, which is highly expressed in vascular endothelial cells and exhibits the same function as vascular endothelial growth factor, and can promote angiogenesis. Recently, it has been found that AGGF1 is highly expressed in various tumors such as liver cancer, leukemia, glioma and gastric cancer. Based on its participation in the regulation of tumor angiogenesis, DNA repair and autophagy, tumors with high expression of AGGF1 are prone to drug resistance and metastasis, and the survival and prognosis of patients are worse. Deep understanding of the roles of AGGF1 in tumor angiogenesis and its specific molecular mechanisms will provide new strategies for antitumor angiogenesis therapy in the future.

Key words: Neoplasms, Neovascularization, pathologic, DNA repair;, Autophagy, AGGF1

Shen Xiabo, Li Yan, Wang Wei. Roles of AGGF1 in tumor and its regulatory mechanisms[J]. Journal of International Oncology, 2019, 46(3): 166-169.

References

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