Relationship between insulin resistance related factors and colon cancer stem cells

doi:10.3760/cma.j.issn.1673-422X.2017.10.017

Journal of International Oncology ›› 2017, Vol. 44 ›› Issue (10): 790-793.doi: 10.3760/cma.j.issn.1673-422X.2017.10.017

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Relationship between insulin resistance related factors and colon cancer stem cells

Wan Lijuan, Chen Mingwei

Department of Endocrinology, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China

Online:2017-10-08 Published:2017-11-08
Contact: Chen Mingwei E-mail:chmw1@163.com
Supported by:
Natural Science Foundation of Anhui Province of China (1508085MH150)

Abstract

Abstract: Colon cancer stem cells have uncontrolled selfrenewal capabilities, a potential of forming colon cancer and resistance to conventional antitumor therapy. Insulin resistance related factors mainly include adiponectin, leptin and various inflammatory factors. Various insulin resistance related factors have different effects on the proliferation, apoptosis, migration, carcinogenesis of colon cancer stem cells through different mechanisms. Understanding the relationship between various insulin resistance related factors and colon cancer stem cells can provide a new treatment for colon cancer.

Key words: Colonic neoplasms, Stem cells, Insulin resistance

Wan Lijuan, Chen Mingwei. Relationship between insulin resistance related factors and colon cancer stem cells[J]. Journal of International Oncology, 2017, 44(10): 790-793.

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Relationship between insulin resistance related factors and colon cancer stem cells

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