Journal of International Oncology ›› 2017, Vol. 44 ›› Issue (10): 787-789.doi: 10.3760/cma.j.issn.1673-422X.2017.10.016

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Roles of interleukin6 in occurrence, development and prognosis of hepatocellular carcinoma

Zhang Bin, Shi Dongmei, Qiao Sen   

  1. School of Medicine and Life Sciences, University of Ji′nan University and Shandong Academy of Medical Sciences, Ji′nan 250062, China
  • Online:2017-10-08 Published:2017-11-08
  • Contact: Qiao Sen E-mail:qsenqiao@sina.com
  • Supported by:
    National Natural Science Foundation of China (81401653); Natural Science Foundation of Shandong Province of China (ZR2015HL127)

Abstract: Interleukin6 (IL6) involves in a variety of inflammatory responses and immune regulation, showing closely correlations to tumor progression. Recent studies reveal that IL6 may play an important role in constituting tumor microenvironment, activating related signal pathway, regulating downstream transcription factors, to affect the proliferation, invasion and metastasis of tumor cells. IL6 has important potential value in the targeted therapy for hepatocellular carcinoma.

Key words: Liver neoplasms, Prognosis, Interleukin6