Journal of International Oncology ›› 2023, Vol. 50 ›› Issue (1): 33-36.doi: 10.3760/cma.j.cn371439-20221005-00006

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Research progress on the mechanism of bone marrow suppression after chemotherapy

Sun Qi1, Li Wenqian2(), Xie Youbang2, Zhou Houfa1   

  1. 1Graduate School of Qinghai University, Xining 810016, China
    2Department of Hematology, Qinghai Provincial People's Hospital, Xining 810000, China
  • Received:2022-10-05 Revised:2022-11-26 Online:2023-01-08 Published:2023-03-16
  • Contact: Li Wenqian E-mail:lwq121616@163.com
  • Supported by:
    Translational Research Grant of National Clinical Research Center for Hematological Diseases(2021WWB04);Project of Qinghai Provincial Clinical Research Center for Hematological Diseases(2021-SF-136)

Abstract:

As an effective treatment for cancer, chemotherapy not only removes tumor cells, but also produces obvious killing effects on proliferating cells, especially hematopoietic cells, resulting in bone marrow suppression after chemotherapy, and affecting the effects of chemotherapy drug treatment and treatment cycle. Therefore, starting from the aspects of hematopoietic microenvironment damage and hematopoietic stem cell aging, to explore the mechanism of myelosuppression after chemotherapy, which provides new ideas and theoretical support for the intervention and management of bone marrow suppression after cancer chemotherapy.

Key words: Hematopoietic stem cells, Cellular senescence, Myelosuppression, Chemotherapy, Hematopoietic microenvironment