Abstract: Fibrinogen (Fib) is one of the most common coagulation proteins, plays an important role in the coagulation cascade, and has a closed relationship with tumor. Studies indicate that the level of Fib has elevated in many kinds of cancer, and Fib is also closely correlated with the progression, metastasis and prognosis of tumor. Though the mechanism of the interaction of Fib and tumor is still unclear, Fib as a tumor marker and new therapy for these malignancies has been a new hotspot.

Key words: Fibrinogen, Neoplasms, Tumor metastasis, Prognosis