Abstract: With the rapid growth of incidence of non-small cell lung cancer (NSCLC), more and more studies have been made about its occurrence, development and metastatic mechanism in recent years. Researches about Fas/FasL protein expression and Fas/FasL-mediated apoptosis, immune escape mechanism and their roles in the pathogenesis, progression and prognosis of lung cancer are constantly emerging. Discussion about the roles of Fas/ FasL system in NSCLC could provide evidence for early diagnosis, prognosis prediction and new treatment of NSCLC.

Key words: Carcinoma, non-small-cell lung, Apoptosis, Tumor escape, Fas