Journal of International Oncology ›› 2013, Vol. 40 ›› Issue (10): 782-784.

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PPARγ and the invasion and metastasis of hepatocellular carcinoma

WANG  Chuang, XUE  Ping, CAO  Liang-Qi   

  1. Department of Hepatobiliary Surgery, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China

  • Online:2013-10-08 Published:2013-09-23
  • Contact: CAO Liang-qi, E-mail: clq0829@163.com E-mail:clq0829@163.com

Abstract: Recent studies indicate that the activation of peroxisome proliferator-activated receptor gamma (PPARγ) can inhibit the invasion and metastasis of hepatocellular carcinoma (HCC) by inhibiting proliferation and adhesion of HCC cells, degradation of extracellular matrix and angiogenesis. Therefore, the mechanisms that PPARγ signaling pathway inhibits the invasion and metastasis of HCC may provide help for the clinical treatment, and is expected to improve the survival rate of HCC patients.

Key words: P而欧系someproliferator-activated receptors, Liver neoplasms, Neoplasm metastasis