Clinical significance of detection of HE4, OPN and uPA in the diagnosis of endometrial carcinoma

doi:10.3760/cma.j.issn.1673422X.2017.05.007

Abstract

Abstract: ObjectiveTo investigate the expressions and relationships of human epididymal secretory protein 4 (HE4), osteopontin (OPN) and urokinasetype plasminogen activator (uPA) in endometrial carcinoma (EC) and analyze their clinical significance of detection and diagnosis in EC patients. MethodsThe expressions of HE4, OPN and uPA proteins in 30 cases of normal endometrium, 50 cases of precancerous lesion endometrium and 171 cases of EC were detected by immunohistochemistry SP method. The relationships between HE4, OPN, uPA and clinicopathological features of EC, and the correlation of them were analyzed. ResultsThe positive expression rates of HE4, OPN and uPA in the normal endometrium group, precancerous lesion endometrium group and EC group were 13.3%, 32.0%, 70.8%；10.0%, 24.0%, 63.7%；6.7%, 22.0%, 51.5%. The differences were statistically significant (χ2=46.36, P<0.05； χ2=44.14, P<0.05； χ2=28.10, P<0.05). The expressions of HE4, OPN and uPA were correlated with pathological stage (χ2=4.644, P=0.031； χ2=5.780, P=0.016； χ2=28.920, P=0.000), histological grade (χ2=4.888, P=0.027； χ2=7.885, P=0.005； χ2=4.564, P=0.033), myometrial invasion depth (χ2=5.099, P=0.024； χ2=5.139, P=0.023； χ2=12.297, P=0.000) and lymph node metastasis (χ2=5.421, P=0.020； χ2=4.093, P=0.043； χ2=5.362, P=0.021). In addition, the expression of HE4 was correlated with the histological type (χ2=4.437, P＝0.035). HE4 expression was positively correlated with uPA expression (r=0.341, P=0.007). OPN expression was positively correlated with uPA expression (r=0.360, P=0.002). HE4 was positively correlated with OPN expression (r=0.454, P=0.000). ConclusionThe expression rates of HE4, OPN and uPA in the EC group were higher than that in normal endometrium and precancerous lesions. They have obvious positive synergistic effect in the occurrence and development of EC. HE4, OPN and uPA are the effective indicators for clinical diagnosis of EC.

Key words: Endometrial neoplasms, Osteopontin, Human epididymis secretory protein 4, Urokinasetype plasminogen activator

LI Mei-Yan. Clinical significance of detection of HE4, OPN and uPA in the diagnosis of endometrial carcinoma[J]. Journal of International Oncology, 2017, 44(5): 351-355.

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