Abstract: ObjectiveTo discuss the expressions and clinicopathologic significances of insulinlike growth factor Ⅱ mRNA binding protein 3 (IMP3) in squamous intraepithelial lesion (SIL) and cervical squamous cell carcinoma (CSCC) before and after the therapy of radiation and chemotherapy. MethodsThe expressions of IMP3 in 80 cases of CSCC, 90 cases of SIL (60 cases of HSIL, 30 cases of LSIL) and 30 cases of cervicitis were detected by immunobistochemistry. The relations between IMP3 and clinicopathological characteristics of CSCC were analyzed. ResultsThe expression rates of IMP3 in CSCC, HSIL, LSIL and cervicitis were 86.3%(69/80), 78.3%(47/60), 33.3%(10/30) and 0(0/30), and the difference among the four groups was statistically signicant (χ2=87.01, P＜0.01). The positive expression rate of IMP3 declined by radiation or chemotherapy (60.0% vs. 85.0%, χ2=5.79, P=0.013). The expression of IMP3 was related with lymph node metastasis (χ2=3.97, P=0.046), differentiated degree (χ2=5.95, P=0.018), clinical stage (χ2=5.82, P=0.016) and invasion depth (χ2=5.73, P=0.017). There was nothing to do with age (χ2=0.11, P=0.745). ConclusionIMP3 expresses excessively in CSCC, and is associated with pathological grade and invasion progress. Radiochemotherapy can reduce the expression of IMP3.

Key words: Uterine cervical neoplasms, Cervical intraepithelial neoplasia, Immunohistochemistry, Radiotherapy, Drug therapy, Insulinlike growth factor Ⅱ mRNA binding protein 3