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08 October 2016, Volume 43 Issue 10 Previous Issue    Next Issue

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Preliminary study on quantitative proteomic analysis of differentially expressed proteins in HER-2 positive and negative breast cancer Li Jing, Huang Sanqian, Ouyang Quchang, Zhong Jingmin, Gao Nina, Liu Liping, Liu Zhihong, Zeng Liang 2016, 43 (10):  721-727.  doi: 10.3760/cma.j.issn.1673-422X.2016.10.001 Abstract ( 361 )   PDF (2145KB) ( 1271 )   Save ObjectiveTo seek differentially expressed proteins for human epithelial growth factor receptor2 (HER2) negative and positive breast carcinoma through establishing proteins profiles, and to provide new prognostic markers and therapeutic targets for patients with breast cancer. MethodsHER2 positive and negative breast cancer protein expression profiles were established using proteomic isobaric tags for relative and absolute quantitation (iTRAQ) technology. Differences of protein expression were identified and parts of differential expression proteins were analyzed by bioinformatics, including protein function annotation and GO classification analysis and Kyoto Encyclopedia of Gene and Genome (KEGG) pathway analysis. ResultsProteomic analysis of breast cancer tissue with identified HER2 positive and negative groups showed 4 999 differentially expressed proteins by iTRAQ. Based on the criteria of the ratio of HER2(+)/HER2(－)≥3, 119 upregulated proteins were identified in HER2 positive group. Based on the criteria of the ratio of HER2(+)/HER2(－)≤0.5, 47 downregulated proteins were identified in HER2 positive group. The results of GO analysis showed that the molecular function, biological process and cellular composition of differentially expressed proteins were complex between HER2 positive and negative breast cancer. There were differences in the distribution of upregulated proteins and downregulation of proteins. KEGG pathway analysis showed that differentially expressed proteins involved in 168 signal pathways. ConclusionThere are differentially expressed proteins between HER2 positive and negative breast cancer, which involve complex molecular function, biological process and signaling pathway. References | Related Articles | Metrics

Correlations between P53 expression and clinicopathologic factors and the prognosis of Luminal breast cancer Song Fangbin, Li Shanbao, Zhang Jianbing, Wu Junyi, Jin Tao, Qin Jun, Wang Ye, Wang Min, Xu Junming 2016, 43 (10):  728-732.  doi: 10.3760/cma.j.issn.1673-422X.2016.10.002 Abstract ( 633 )   PDF (924KB) ( 1401 )   Save ObjectiveTo investigate the correlations between P53 expression and clinicopathologic factors and prognosis of Luminal breast cancer. MethodsFrom January 2009 to December 2012, a total of 283 patients with Luminal breast cancer in the Shanghai General Hospital Affiliated to Shanghai Jiaotong University were included. P53 expressions of them were assayed by immunohistochemistry. Survival analysis was applied using KaplanMeier curve and Logrank test. Single factor analysis and mutiplefactor analysis were applied using Cox proportional hazard regression model. ResultsThe rate of P53 expression was associated with tumor size (χ2=6.285, P=0.043), lymph node metastasis (χ2=15.881, P=0.000), histological grade (χ2=8.132, P=0.043) and Ki67 (χ2=6.476, P=0.039), but it was not associated with age (χ2=0.955, P=0.328), menopausal status (χ2=3.808, P=0.051), pathological pattern (χ2=0.847, P=0.655), estrogen receptor (χ2=1.867, P=0.172), progesterone receptor (χ2=0.937, P=0.333) and human epidermal growth factor receptor2 (χ2=0.110, P=0.741). In all the 283 patients, the 5year relapsefree survival rates for P53positive group and P53negative group were 66.7% and 90.7% respectively (χ2=12.609, P=0.000), while the 5year overall survival rates were 84.4% and 93.4% respectively (χ2=4.153, P=0.042), with significant differences. In Cox mutiplefactor analysis, lymph node metastasis (HR=2.484, 95%CI: 1.3934.431, χ2=9.497, P=0.002) and P53 overexpression (HR=3.627, 95%CI: 1.06112.401, χ2=4.220, P=0.040) were independent prognostic factors for the relapsefree survival of patients with Luminal breast cancer, and lymph node metastasis (HR=3.451, 95%CI: 1.8916.297, χ2=16.290, P=0.000) and higher histological grade (HR=2.806, 95%CI: 1.0917.219, χ2=4.582, P=0.032) were independent prognostic factors for overall survival. ConclusionP53 overexpression of patients with Luminal breast cancer is associated with prognostic factors such as lymph node metastasis and histological grade, which indicates the worse prognosis. References | Related Articles | Metrics

Ki-67 and AR expression and its relationship with recurrence in triplenegative breast cancer Yang Wenli, Peng Yu, Shen Wang, Deng Xinghui, Li Ronggang, Liu Qiongru 2016, 43 (10):  733-736.  doi: 10.3760/cma.j.issn.1673-422X.2016.10.003 Abstract ( 630 )   PDF (700KB) ( 1372 )   Save ObjectiveTo investigate the expressions of cellular proliferative antigen (Ki67) and androgen receptor (AR) in triplenegative breast cancer (TNBC) and their relationships with recurrence. MethodsSixtysix cases of TNBC and two hundred and fifteen cases of non triplenegative breast cancer (NTNBC) tissues between January 2006 and December 2010 in Jiangmen Hospital Affiliated to Sun Yatsen University were collected, the expressions of Ki67 and AR were detected by immunohistochemical, and through followup the relationships between TNBC recurrence and the expressions of Ki67 and AR were analyzed. SPSS 19.0 was used to analyze the results. ResultsThe positive rate of Ki67 in TNBC (75.76%, 50/66) was significantly higher than that in NTNBC (62.33%, 134/215, χ2=4.031, P=0.045), and Ki67 expression was correlated with histological grade (χ2=6.031, P=0.049), tumor diameter (χ2=6.630, P=0.036) and lymph node metastasis (χ2=5.440, P=0.020). The positive rate of AR in TNBC (31.82%, 21/66) was significantly lower than that in NTNBC (76.28%, 164/215, χ2=44.382, P＜0.001), and AR expression was correlated with menopausal status (χ2=5.341, P=0.021) and body mass index (χ2=4.369, P=0.037). TNBC recurrence was related to Ki67 expression (χ2=4.125, P=0.042), and was not related to AR expression (χ2=1.257, P=0.262). ConclusionHigh expression level of Ki67 and low expression level of AR are characteristics of TNBC. Ki67 positive patients are more likely to relapse, and it can be used as an indicator to predict TNBC recurrence. References | Related Articles | Metrics

Analysis of human papillomavirus infection in nonsmall cell lung cancer Yan Ying, He Yifu, Li Ming 2016, 43 (10):  737-740.  doi: 10.3760/cma.j.issn.1673-422X.2016.10.004 Abstract ( 455 )   PDF (699KB) ( 1243 )   Save ObjectiveTo detect the infection of human papillomavirus (HPV) in patients with nonsmall cell lung cancer (NSCLC) and explore the relationship between HPV infection and clinicopathological features. MethodsHPV detection and genotyping in 156 cases of NSCLC were performed using a new liquid chip based on Luminex. Patient clinical characteristics were also recorded, and the relationship between HPV infection and clinicopathological features was studied. ResultsOf the 156 tumorDNA samples tested, 40 (25.6%) cases showed presence of HPVDNA, of which 37 cases were of a highrisk HPV type (16, 18, 33, 58). The differences were statistically significant between the HPVpositive and HPVnegative groups in gender (χ2=4.387, P=0.036), smoking (χ2=8.130, P=0.004), histologic type (χ2=4.075, P=0.044) and lymph node metastasis (χ2=7.082, P=0.008). The differences were not statistically significant between the HPVpositive and HPVnegative groups in age (χ2=0.013, P=0.910), differentiated degree (χ2=1.727, P=0.189), clinical stages (χ2=0.179, P=0.672), distant metastasis (χ2=3.012, P=0.083). Logistic regression analysis revealed that lymph node metastasis alone was an independent predictive factor of HPV infection in NSCLC (OR=0.384, 95%CI: 0.1530.967, P=0.042), and gender (OR=1.402, 95%CI: 0.5223.769, P=0.503), smoking (OR=0.506, 95%CI: 0.1941.322, P=0.506), histologic type (OR=0.393, 95%CI: 0.1330.161, P=0.091) were not independent predictive factors of HPV infection.ConclusionThe infection of HPV presents in part of Chinese NSCLC patients, and HPV infection may be connected with occurrence and development of lung cancer. References | Related Articles | Metrics

Clinical curative effect on nonsmall cell lung cancer patients by cinobufacini injection combined firstline chemotherapy Cao Jie, Zhou Jian, Yang Di, Chu Jin 2016, 43 (10):  741-743.  doi: 10.3760/cma.j.issn.1673-422X.2016.10.005 Abstract ( 402 )   PDF (693KB) ( 1409 )   Save ObjectiveTo explore the clinical curative effect on nonsmall cell lung cancer (NSCLC) patients by cinobufacini injection combined with firstline chemotherapy. MethodsEighty patients with NSCLC from January 2013 to January 2015 in our hospital were selected as the research objects. Then they were divided into the observation group (n=40) and the control group (n=40) by random number tables. The patients in control group accepted docetaxel and cisplatin combination chemotherapy regimens (TP). While the observation group accepted cinobufacini injection on the basis of the control group. Then the local control, adverse reactions and prognosis of the two groups were compared. ResultsThe local control of observation group was 77.5%, while the control group was 62.5%, the local control of observation group was obviously higher than that of the control group (χ2=5.36, P=0.03). Leucopenia incidence of the observation group was 27.5%, the control group was 50.0%, and the incidence of the observation group was obviously lower than that of the control group (χ2=4.27, P=0.04). There was no statistically significant difference between the two groups in diarrhea, stomachache, vomiting, tinnitus (17.5% vs. 27.5%, χ2=1.15， P=0.28； 25.0% vs. 45.0%, χ2=3.52， P=0.06;  5.0% vs. 7.5%, χ2=0.34， P=0.56； 7.5% vs. 10.0%, χ2=0.16， P=0.69). There was statistically significant difference between the two groups in median survival time (97 d vs. 45 d, HR=8.934, χ2=9.928, P＜0.05). ConclusionThe cinobufacini injection combined with docetaxel can effectively reduce the incidence of myelosuppression, and improve survival and local control with high safety, and the clinical effect is remarkable and can improve the prognosis of patients. References | Related Articles | Metrics

Expressions of IMP3 in cervical squamous cell carcinoma before and after the therapy of radiation and chemotherapy Nie Jia, Wu Ning, Zhang Lixia, Huang Yifan, Liu Jun 2016, 43 (10):  744-747.  doi: 10.3760/cma.j.issn.1673-422X.2016.10.006 Abstract ( 573 )   PDF (1080KB) ( 1296 )   Save ObjectiveTo discuss the expressions and clinicopathologic significances of insulinlike growth factor Ⅱ mRNA binding protein 3 (IMP3) in squamous intraepithelial lesion (SIL) and cervical squamous cell carcinoma (CSCC) before and after the therapy of radiation and chemotherapy. MethodsThe expressions of IMP3 in 80 cases of CSCC, 90 cases of SIL (60 cases of HSIL, 30 cases of LSIL) and 30 cases of cervicitis were detected by immunobistochemistry. The relations between IMP3 and clinicopathological characteristics of CSCC were analyzed. ResultsThe expression rates of IMP3 in CSCC, HSIL, LSIL and cervicitis were 86.3%(69/80), 78.3%(47/60), 33.3%(10/30) and 0(0/30), and the difference among the four groups was statistically signicant (χ2=87.01, P＜0.01). The positive expression rate of IMP3 declined by radiation or chemotherapy (60.0% vs. 85.0%, χ2=5.79, P=0.013). The expression of IMP3 was related with lymph node metastasis (χ2=3.97, P=0.046), differentiated degree (χ2=5.95, P=0.018), clinical stage (χ2=5.82, P=0.016) and invasion depth (χ2=5.73, P=0.017). There was nothing to do with age (χ2=0.11, P=0.745). ConclusionIMP3 expresses excessively in CSCC, and is associated with pathological grade and invasion progress. Radiochemotherapy can reduce the expression of IMP3. References | Related Articles | Metrics

Influence of elemene on curative effect and life quality for patients with recurrent ovarian cancer with ascites Wang Zixi 2016, 43 (10):  748-751.  doi: 0.3760/cma.j.issn.1673-422X.2016.10.007 Abstract ( 325 )   PDF (878KB) ( 927 )   Save ObjectiveTo explore the effect of elemene on recurrent ovarian cancer with ascites and the impact on the life quality. MethodsFrom August 2013 to July 2015, 64 patients with recurrent ovarian cancer with ascites in Huangdao District Hospital of Traditional Chinese Medicine of Qingdao were collected. They were divided into control group (n=32) and observation group (n=32) by random number table. Patients in observation group were treated with elemene and cisplatin by intraperitoneal perfusion, and patients in control group were treated with cisplatin alone. The effects and life quality were compared between the two groups. ResultsThere were 10 cases of complete response (CR), 13 cases of partial response (PR), 6 cases of stable disease (SD), 3 cases of progressive disease (PD), 71.88% of overall response rate (ORR) in the control group; and there were 19 cases of CR, 9 cases of PR, 3 cases of SD, 1 case of PD, 87.50% of ORR in the observation group, with significant difference (Z=-2.312, P=0.021). There were significant differences about the physical function (61.66±9.27 vs. 51.66±15.73; t=-3.102, P=0.003), role function (59.89±13.29 vs. 45.83±19.40; t=-3.383, P=0.001), emotional function (49.73±11.29 vs. 30.72±13.45; t=-6.120, P=0.000), cognitive function (62.50±13.39 vs. 50.00±19.40; t=-3.000, P=0.004), total health status (54.69±10.99 vs. 42.97±14.98; t=-3.568, P=0.001), symptoms of fatigue (38.53±13.23 vs. 47.57±19.39; t=2.175, P=0.033), nausea and vomiting scores (19.27±4.77 vs. 36.45±12.29; t=5.483, P=0.000) and symptoms of insomnia (23.95±10.77 vs. 38.54±11.46; t=2.216, P=0.030) between the observation and control groups. There were no differences about the social function (37.50±17.96 vs. 36.97±16.79; t=-0.120, P=0.905), symptoms of pain (23.43±9.58 vs. 22.92±9.19; t=-0.118, P=0.906), difficult breathing (19.79±6.49 vs. 16.67±5.74; t=-0.606, P=0.547), anorexia (63.54±25.90 vs. 66.67±18.93; t=0.551, P=0.584), constipation (27.08±10.59 vs. 23.96±9.14; t=-0.545, P=0.588), diarrhea (63.54±25.90 vs. 66.67±18.93; t=0.551, P=0.584) and economic hardship (60.41±21.03 vs. 65.62±29.91; t=0.683, P=0.497) between the observation and control groups. ConclusionElemene combined with cisplatin achieves the better efficacy on recurrent ovarian cancer with ascites by intraperitoneal perfusion, which has the potential to further improve the patient′s life quality, and deserves to be studied and promoted application. References | Related Articles | Metrics

Association between XPC rs2228000(C/T) polymorphism and the susceptibility of breast cancer: a Metaanalysis Cui Jing, Tan Hui, Jiang Lei, Yuan Wenzhen, Guan Quanlin 2016, 43 (10):  752-757.  doi: 10.3760/cma.j.issn.1673-422X.2016.10.008 Abstract ( 333 )   PDF (878KB) ( 891 )   Save ObjectiveTo quantitatively examine the relationship between xeroderma pigmentosum complementation C group (XPC) rs2228000(C/T) polymorphism and the susceptibility of breast cancer. MethodsThe relevant casecontrol studies published up to December 2015 which investigated XPC rs2228000(C/T) polymorphism and breast cancer risk were identified by searching PubMed, Cochrane Library, Chinese Biomedical Literature Data, Wanfang Database, China National Knowledge Infrastructure and VIP Database. Metaanalysis was conducted using STATA 12.0 software and odds ratio (OR) with its 95%CI were estimated. ResultsA total of 8 researches involving 9 casecontrol studies (3 850 breast cancer cases and 5 047 healthy controls) were included. The Metaanalysis showed that there was statistical association between XPC rs2228000(C/T) variance and breast cancer risk in the homozygous model (TT vs. CC: OR=1.28, 95%CI: 1.081.52, Z=2.80, P=0.005) and recessive model (TT vs. TC+CC: OR=1.23, 95%CI: 1.051.43, Z=2.64, P=0.008), but not in the allele model, heterozygote model and dominant model. In the subgroup of ethnicity and genotyping methods, the different significant correlation was existed between them under Asian and PCRRFLP in genetic models (T vs. C: OR=1.21, 95%CI: 1.051.40, Z=2.63, P=0.009; TT vs. CC: OR=1.55, 95%CI: 1.132.13, Z=2.70, P=0.007; TT+TC vs. CC: OR=1.26, 95%CI: 1.021.55, Z=2.19, P=0.028; TT vs. TC+CC: OR=1.39, 95%CI: 1.041.87, Z=2.23, P=0.026). We also found significant association between them in subgroup of populationbased controls in the homozygous model (TT vs. CC: OR=1.27, 95%CI: 1.021.57, Z=2.16, P=0.031). ConclusionXPC rs2228000(C/T) polymorphism may be associated with the susceptibility of breast cancer, especially in Asian, and genetype TT may increase the risk of breast cancer. References | Related Articles | Metrics

Dietary fiber intake and risk of prostate cancer: a Metaanalysis Liu Weishuai, Zeng Yaqi, Shao Yuejuan, Wang Kun 2016, 43 (10):  758-764.  doi: 10.3760/cma.j.issn.1673-422X.2016.10.009 Abstract ( 523 )   PDF (1758KB) ( 1297 )   Save ObjectiveTo determine the relationship between dietary fiber intake and risk of prostate cancer. MethodsElectronic databases including PubMed, EMBase, Cochrane library, China National Knowledge Internet (CNKI), Wanfang and CBM were searched  to find eligible studies. Randomeffects relative risk (RR) and its corresponding 95%CI were used. Besides, randomeffects doseresponse analyses were also performed to clarify the doseresponse relations. ResultsTen studies, including five cohort studies and five casecontrol studies, were eligible and included in this Metaanalysis. The pooled RR of prostate cancer for the highest compared with the lowest dietary fiber intake was 0.87 (95%CI: 0.770.99, Z=2.10, P=0.035). In addition, pooled estimated data showed that risk of prostate cancer was significantly associated with soluble fiber (RR=0.78, 95%CI: 0.640.95, Z=2.45, P=0.014) and insoluble fiber (RR=0.65, 95%CI: 0.450.88, Z=2.79, P=0.005), but not with fruit, vegetable and cereal fiber intake. However, in doseresponse analysis, no significant association was reported （RR=0.996， 95%CI： 0.9891.002）. Sensitivity analysis showed that the overall results were relatively stable, and omission of any single study had little effect on the combined results. ConclusionDietary fiber intake is negative related to the risk of prostate cancer. Intake of dietary fiber is recommended to prevent prostate cancer. Considering the limitations of the included studies, more welldesigned prospective studies will be needed to confirm our findings. References | Related Articles | Metrics

Anticancer effect and mechanism of miR-139 Zhai Junshan, Li Nan 2016, 43 (10):  765-768.  doi: 10.3760/cma.j.issn.1673-422X.2016.10.010 Abstract ( 518 )   PDF (699KB) ( 1139 )   Save MicroRNA (miRNA) is closely related to the occurrence and development of neoplasms. miR139 is a tumorsuppressive miRNA and its expression is decreased in a variety of tumor tissues, while overexpression of miR139 can inhibit cancer cell proliferation, migration, invasion and induce cell apoptosis by suppressing the expression of multiple kinds of target genes. Therefore, miR139 has potential applications in tumor diagnosis, treatment and prognosis assessment. References | Related Articles | Metrics

Relationship between lymphocytemonocyte ratio and prognosis of malignant tumors Qian Menlong, Lu Ning 2016, 43 (10):  769-771.  doi: 10.3760/cma.j.issn.1673-422X.2016.10.011 Abstract ( 832 )   PDF (693KB) ( 1983 )   Save Related studies have been confirmed that tumorassociated inflammation is associated with tumor progression and prognosis in a variety of tumors. As an inflammatory biomarker, lymphocytemonocyte ratio shows significant value in predicting the prognosis of malignant tumors. It can not only be appropriate for patients with cancer risk stratification, but also provide the basis for the subsequent development of individualized treatment programs. References | Related Articles | Metrics

Research progress of immunoscore Zhao Xinru, Zhao Yuye, Li Guohong, Kan Xuan, Niu Zuoxing 2016, 43 (10):  772-774.  doi: 10.3760/cma.j.issn.1673-422X.2016.10.012 Abstract ( 589 )   PDF (692KB) ( 1786 )   Save A methodology named "immunoscore" has been proposed in recent years. It has been demonstrated to be a prognostic factor superior to the Union for International Cancer ControlAmerican Joint Committee on Cancer (UICCAJCC) TNM classification. Over the past few years, it has gained a forefront position in colorectal cancer. It has the advantages of simple operation, low cost and high accuracy, and it is needed for individual therapy. However, it still has its limitations. References | Related Articles | Metrics

Evidencebased interventional pain management techniques commonly used in clinical cancer pain Ji Kai, Shao Yuejuan, Wang Kun 2016, 43 (10):  775-778.  doi: 10.3760/cma.j.issn.1673-422X.2016.10.013 Abstract ( 309 )   PDF (695KB) ( 1193 )   Save Cancer pain can seriously disturb patients′ quality of life. Intractable cancer pain not amenable to standard analgesics is a horrifying truth in parts of the patients. Interventional pain management techniques can be an effective alternative for those patients. Based on the evidence of evidencebased medicine, celiac plexus block or splanchnic nerve block are recommended for the management of upper abdominal cancer pain, pelvic cancer pain can be managed with superior hypogastric plexus block, and back pain due to vertebral compression fractures with tumor invasion can be managed with percutaneous vertebroplasty or kyphoplasty. Intercostal nerve block for chest wall cancer pain, ganglion impar block and saddle block for perineal pain due to pelvic tumors should be used only in the context of an experimental study or in cases of compassionate use with no other available forms of effective pain relief. References | Related Articles | Metrics

Roles of Hippo-TAZ signaling pathway in breast cancer and breast cancer stem cells Yan Bing, Lu Ying, Zhang Chunying, Li Qing, Mao Jun, Li Lianhong 2016, 43 (10):  779-782.  doi: 10.3760/cma.j.issn.1673-422X.2016.10.014 Abstract ( 390 )   PDF (700KB) ( 1538 )   Save Hippo signaling pathway plays an important role in the regulation of organ growth, tissue regeneration, tumor occurrence and development. Transcriptional coactivator with PDZbinding motif (TAZ) is the downstream transcription factor of Hippo signaling, participates in the regulation of the entire signaling pathway. In recent years, many studies have found that overexpression of TAZ has a close relationship with the occurrence, development and prognosis of breast cancer. Discussing the relationship of HippoTAZ with breast cancer and breast cancer stem cells may provide a new way for breast cancer diagnosis and treatment. References | Related Articles | Metrics

Expression and role of microtubuleassociated protein in breast cancer Huang Sanqian, Li Jing, Liu Zhihong, Zeng Liang 2016, 43 (10):  783-786.  doi: 10.3760/cma.j.issn.1673-422X.2016.10.015 Abstract ( 361 )   PDF (702KB) ( 1441 )   Save In recent years, many new microtubuleassociated proteins are found or studied extensively in the treatment of breast cancer. Endbinding protein 1 (EB1) has the promotional effects on cell proliferation and enhances the carcinogenesis of breast cancer, and also can affect the chemosensitivity of the treatment. MAP7 domaincontaining protein 3 (Mdp3) expresses in breast epithelial cells and plays an important role on the growth and metastasis. Nucleolar and spindleassociated protein (NuSAP) gene is upregulated in breast cancer and is considered as a biomarker for breast cancer. Tau expression level has a strong correlation with estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor2 (HER2), and it remains controversial in the results of the effect of paclitaxel chemotherapy and hormone treatment. References | Related Articles | Metrics

Chemokines and lung cancer Li Guodong, Ouyang Weiwei, Su Shengfa, Ma Zhu, Li Qingsong, Wang Yu, Lu Bing 2016, 43 (10):  787-790.  doi: 10.3760/cma.j.issn.1673-422X.2016.10.016 Abstract ( 444 )   PDF (698KB) ( 1332 )   Save Chemokines and chemokine receptors involve in biological activity and pathological process widely. It has been reported that many tumor cells overexpress functional chemokines. In lung cancer, chemokines involve in its proliferation, apoptosis, invasion and metastasis. Chemokines and chemokine receptor overexpressed in lung cancer can be used as specific target for pertinent antitumor treatment. References | Related Articles | Metrics

Current status and recent advances of lymph node micrometastase in patients with gastric cancer Zhou Yang, Fu Weihua 2016, 43 (10):  791-794.  doi: 10.3760/cma.j.issn.1673-422X.2016.10.017 Abstract ( 436 )   PDF (699KB) ( 1880 )   Save There is still a certain recurrence rate after extensive lymphadenectomy even to patients with nodenegative gastric cancer. It promotes the researchers to use a more sensitive and effective way to track tumor cells which are missed, especially lymph node micrometastases. With the development of detection technology, the diagnostic rate of micrometastasis is significantly increased. There are so many controversies about the impact of lymph node micrometastases that no consensus on the clinical treatment can be reached. In recent years, with the rise of endoscopic therapy, how to balance the relationship between the quality of  life and the safety makes the research of micrometastases more urgent. References | Related Articles | Metrics