Role of CMTM6 and CMTM4 protein in tumorigenesis， development and prognosis

doi:10.3760/cma.j.cn371439-20240328-00119

Abstract

Abstract:

The CKLF-like MARVEL transmembrane domain containing family of genes （CMTM） family plays a crucial role in tumorigenesis， development， metastasis， and drug resistance. CMTM6 and CMTM4 are key proteins that regulate the stability of programmed death-ligand 1 （PD-L1） and play an important role in tumor immunotherapy resistance in particular. At present， the detailed molecular mechanisms linking CMTM6 and CMTM4 with tumors have not been fully understood. In-depth study of the expression， biological role and regulatory mechanism of CMTM4 and CMTM6 in tumors will provide new ideas and targets for the diagnosis， treatment and prediction of prognosis of tumors.

Key words: CMTM6, CMTM4, Neoplasms, Drug resistance

Ma Mingzhu, Gao Xiaoling. Role of CMTM6 and CMTM4 protein in tumorigenesis， development and prognosis[J]. Journal of International Oncology, 2024, 51(11): 706-711.

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