Application of immune checkpoint inhibitors combined with radiotherapy in non-small cell lung cancer

doi:10.3760/cma.j.cn371439-20210126-00134

Abstract

Abstract:

The emergence of immune checkpoint inhibitors (ICIs) has greatly changed the treatment strategy of non-small cell lung cancer (NSCLC). Although ICIs are effective, there are still many patients who cannot benefit from immunotherapy alone. The current research direction focuses on the combination of multiple treatment schemes. Radiotherapy can upregulate immunogenic cell surface markers, and regulate the expressions of immune checkpoints. A large number of preclinical and clinical studies are exploring the efficacy and safety of ICIs combined with radiotherapy in various clinical stages of NSCLC, including radiotherapy timing, optimal dose, dose distribution and so on.

Key words: Immunotherapy, Radiotherapy, Carcinoma, non-small-cell lung

Wang Peiwei, Weng Yiming, Cui Xue, Peng Min. Application of immune checkpoint inhibitors combined with radiotherapy in non-small cell lung cancer[J]. Journal of International Oncology, 2021, 48(11): 678-682.

References 39

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