Mechanism of PD-L1 in thyroid carcinoma and its application in diagnosis and treatment

doi:10.3760/cma.j.cn371439-20201208-00109

Abstract

Abstract:

Programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) participate in the regulation of immune checkpoint and are closely related to the occurrence and development of thyroid carcinoma. PD-L1 is expressed differently in different types of thyroid cancer and can be used as a biomarker for the diagnosis of some tumors. The expression of PD-L1 in thyroid cancersis associated with higher tumor invasiveness and higher risk of recurrence. PD-1/PD-L1 immune checkpoint is a promising target for the treatment of some thyroid cancers. Further discussion of the mechanism of PD-1/PD-L1 pathway and its role in the diagnosis and treatment of thyroid cancer and the biomarkers related to the therapeutic effect can provide new ideas for the diagnosis and treatment of thyroid cancer.

Key words: Thyroid neoplasms, Suppressor factors, immunologic, Prognosis, Programmed death-ligand 1

Wu Yuping, Zhang Xiaoyu, Lu Keyi. Mechanism of PD-L1 in thyroid carcinoma and its application in diagnosis and treatment[J]. Journal of International Oncology, 2021, 48(9): 560-563.

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