Research progress in predictive biomarkers related to tumor immunotherapy

doi:10.3760/cma.j.cn371439-20191105-00062

Abstract

Abstract:

Tumor immunotherapy is a treatment method mainly for programmed cell death-1 (PD-1) and its ligand PD-L1. PD-1/PD-L1 inhibitors have obvious clinical benefits and long-lasting responses in a variety of tumors. But overall response rates are still low. Studies show that PD-L1 and tumor mutation burden can predict the effect of immunotherapy. MSI-H/dMMR, TP53 and KRAS mutations are positively correlated with the effect of immunotherapy. While MDM2/4, EGFR, ALK and other genes are negatively correlated with the effect of immunotherapy.

Key words: Neoplasms, Immunotherapy, Biomarkers

Zhang Min, Zhou Lina, Xu Shanshan, Chen Jun. Research progress in predictive biomarkers related to tumor immunotherapy[J]. Journal of International Oncology, 2020, 47(8): 487-491.

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