国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (10): 764-766.doi: １０．３７６０／ｃｍａ．ｊ．ｉｓｓｎ．１６７３４２２Ｘ．２０１４．１０．０１４

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肝癌相关微小RNA的研究进展

邢慧慧,刘晓峰,刘长江   

  1. ２５００３１济南军区总医院消化内科
  • 出版日期:2014-10-29 发布日期:2014-10-11
  • 基金资助:

    山东省自然科学基金（ＺＲ２０１１ＨＭ０２１）

Research progress of liver cancer related microRNA

 XING  Hui-Hui, LIU  Xiao-Feng, LIU  Chang-Jiang   

  1. Department of Gastroenterology, Ji′nan Military General Hospital,  Ji′nan 250031, China
  • Online:2014-10-29 Published:2014-10-11
  • Contact: ＬｉｕＸｉａｏｆｅｎｇ E-mail:ｌｉｕｘｆ０５３１＠１２６．ｃｏｍ

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摘要： 微小ＲＮＡ（ｍｉＲＮＡ）是一类具有转录后调节功能的非编码单链的小分子ＲＮＡ，其在肿瘤形 成过程中的作用已成为目前研究的热点。大量研究提示多种 ｍｉＲＮＡ的异常表达参与了肝癌的发生发 展，并可用于肝癌的诊断、治疗和预后评估。深入探讨 ｍｉＲＮＡ与肝癌的关系及其分子机制将为肝癌的 防治提供新的思路和方法。

关键词: 肝肿瘤, 微 ＲＮＡｓ, 治疗

Abstract: As a noncoding singlestrand small RNA, microRNA (miRNA)  plays an important role in posttranslational regulation. Its role in tumor formation has become a study hotspot. A large body of studies indicate that the abnormal expression of miRNA involves in the occurrence and development of liver cancer, which can be used for the diagnosis, therapy and prognosis evaluation of liver cancer. Indepth exploration of the molecular mechanism of miRNA and the relationship between miRNA and liver cancer could provide novel ideas and methods for the therapy and prevention of liver cancer.

Key words: Liver neoplasms, MicroRNAs, Therapy