国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (10): 767-770.doi: １０．３７６０／ｃｍａ．ｊ．ｉｓｓｎ．１６７３４２２Ｘ．２０１４．１０．０１５

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胰腺癌预后相关免疫组织化学标志物研究进展

祝鹏,刘慧颖,胡志前,王伟军   

  1. ２００００３上海，第二军医大学附属长征医院普外科（祝
    鹏、胡志前、王伟军）；第二军医大学附属东方肝胆外科医院分子肿瘤
    实验室（刘慧颖）
  • 出版日期:2014-10-29 发布日期:2014-10-11
  • 通讯作者: 王伟军，Ｅｍａｉｌ：６１０２０７４９４＠ｑｑ．ｃｏｍ E-mail:６１０２０７４９４＠ｑｑ．ｃｏｍ

Research progress of immunohistochemical markers related with pancreatic cancer prognosis

 ZHU  Peng, LIU  Hui-Ying, HU  Zhi-Qian, WANG  Wei-Jun   

  1. Department of General Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
  • Online:2014-10-29 Published:2014-10-11
  • Contact: ＷａｎｇＷｅｉｊｕｎ E-mail:６１０２０７４９４＠ｑｑ．ｃｏｍ

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摘要： 虽然胰腺癌诊断与治疗的方法和技术已取得长足的进步，但是胰腺癌患者的预后依然得 不到很大提升，这与胰腺癌细胞的恶性程度不无关系。研究表明，正常胰腺细胞在恶化成胰腺癌细胞的 过程中，共需要具备６种能力，这些能力与胰腺癌细胞的恶性程度密切相关。多种与胰腺癌预后相关的 免疫组织化学标志物参与了胰腺细胞获得这６种能力的过程。

关键词: 　胰腺肿瘤, 预后, 肿瘤标记, 生物学

Abstract: Pancreatic cancer is a malignant with very poor prognosis. Although methods and technologies of diagnosis and treatment in connection with pancreatic cancer have made great progresses, the prognoses of patients with pancreatic cancer still have not a significant upgrade, which are closely related with the degree of malignancy of pancreatic cancer cells. Earlier studies have shown that normal pancreatic cells need to have a total of six capabilities, which are intimate connection with the degree of malignancy of pancreatic cancer cells, during the process of deterioration. A variety of immunohistochemical markers that correlate with prognosis of pancreatic cancer involve in the process of pancreatic cells obtaining these six capabilities.

Key words: Pancreatic neoplasms, Prognosis, Tumor markers,biological