国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (8): 647-650.

• 综述 • 上一篇    下一篇

线粒体蛋白NDUFS3与肿瘤

王培,程晓东,谢幸   

  1. 310006 杭州，浙江大学医学院附属妇产科医院女性生殖健康重点实验室
  • 出版日期:2012-09-22 发布日期:2012-09-24
  • 通讯作者: 谢幸，E-mail:xiex@zju.edu.cn E-mail:xiex@zju.edu.cn
  • 基金资助:

    国家自然科学基金资助项目（81072119）

Mitochondrial protein NDUFS3 and tumor

 WANG  Pei, CHENG  Xiao-Dong, XIE  Xing   

  1. Key Laboratory of Female Reproductive Health, Obstetrics and Gynecology Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
  • Online:2012-09-22 Published:2012-09-24
  • Contact: XIE Xing, E-mail:xiex@zju.edu.cn E-mail:xiex@zju.edu.cn

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摘要： 烟酰胺腺嘌呤二核苷酸脱氧酶铁-硫蛋白3(NDUFS3)是线粒体烟酰胺腺嘌呤二核苷酸脱氢酶Ⅰ复合物的基本亚单位之一，在线粒体Ⅰ型呼吸过程中至关重要。早期研究中该基因突变主要导致Leigh综合征等神经变性疾病。近年来观察到NDUFS3在肿瘤细胞中表达下调，推测可能与肿瘤发生发展存在密切关系。

关键词: 线粒体, 肿瘤, 蛋白质类

Abstract: NDUFS3 is an essential subunit of mitochondrial NADH: ubiquinone oxidoreductase (complex Ⅰ) and plays a critical role in the mitochondrial type Ⅰrespiration chain. Mutations in this gene are shown to cause neurodegenerative disease such as Leigh syndrome(subacute necrotizing encephalopathy). In recent years, many evidences show that the expression of NDUFS3 proteins are lower in many cancerous cells compared to the corresponding normal cells. It comes to the conclusion that NDUFS3 may play a role in the tumorigenesis. 

Key words: Mitochondria, Neoplasms, Proteins