国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (8): 643-646.

• 综述 • 上一篇    下一篇

miR-19与肿瘤

孙即奎,贾志凡,杨卫东   

  1. 300052 天津医科大学总医院神经病学研究所神经肿瘤室；天津医科大学总医院神经外科
  • 出版日期:2012-09-22 发布日期:2012-09-24
  • 基金资助:

    国家自然科学基金资助项目（30872985）；天津市应用基础研究计划面上项目（06YFJMJCO7900）

MicroRNA-19 and neoplasms

 SUN  Ji-Kui, JIA  Zhi-Fan, YANG  Wei-Dong   

  1. Department of Neurosurgery and Lab of Neuro-oncology, Tianjin Neurological Institute, Tianjin Medical University General Hospital Tianjin 300052，China
  • Online:2012-09-22 Published:2012-09-24

PDF

2478

被引次数

6

摘要： miR-17~92基因簇编码6种成熟的miRNA，包括miR-17、miR-20a、miR-18a、miR-19a、miR-19b和miR-92a-1，是一类典型的致癌多作用子miRNA。miR-19（包括miR-19a和miR-19b）是其中最重要的致癌miRNA，在淋巴瘤、白血病、肺癌、乳腺癌、多发性骨髓瘤等肿瘤中均表达上调，成为研究的热点之一。miR-19可通过抑制靶基因如PTEN、PP2A、Bim、SOCS1等促进肿瘤的增殖、侵袭和转移，与PI3K-AKT-mTOR信号转导通路关系密切，在肿瘤的发生发展中起着非常重要的作用。

关键词: miR-19, 肿瘤, 淋巴瘤, 白血病

Abstract: The miR-17-92 cluster, consisting of six individual microRNAs, including miR-17, miR-20a,miR-18a, miR-19a, miR-19b and miR-92a-1, is a kind of typical oncogenic polycistron microRNA. MiR-19 (containing miR-19a and miR-19b), as the key oncogenic component in miR-17-92 cluster, is overexpressed in human cancers including lymphomas, leukaemia, lung cancer, breast cancer and multiple myeloma, and has been one of research focus in recent years. It is found that miR-19 promotes tumor growth，invasion and metastasis through negative regulation of target genes such as PTEN, PP2A, Bim,SOCS1, and is correlated strongly with PI3K-AKT-mTOR pathway. MiR-19 plays an important role in tumor genesis and development.

Key words: miR-19, Neoplasms, Lymphoma, Leukemia