循环肿瘤细胞的富集方法与临床应用

doi:10.3760/cma.j.cn371439-20200629-00033

国际肿瘤学杂志 ›› 2021, Vol. 48 ›› Issue (3): 167-171.doi: 10.3760/cma.j.cn371439-20200629-00033

循环肿瘤细胞的富集方法与临床应用

宁大为¹, 欧洋², 崔凯¹, 李胜³, 高德海^3,^*()

¹山东省肿瘤防治研究院(山东省肿瘤医院)肝胆外科,山东第一医科大学(山东省医学科学院),济南 250117
²济南市第五人民医院普通外科 250022
³山东第一医科大学(山东省医学科学院)成果转化与产业部(服务地方经济办公室),济南 250021

收稿日期:2020-06-29 修回日期:2020-09-09 出版日期:2021-03-08 发布日期:2021-03-25
通讯作者: 高德海 E-mail:sdywyjy@126.com
基金资助:
山东第一医科大学学术提升计划(2019QL004);2019年度济南市“高校20条”资助项目(2019GXRC020);山东省重点研发计划(2017CXGC1204)

Enrichment methods and clinical application of circulating tumor cells

Ning Dawei¹, Ou Yang², Cui Kai¹, Li Sheng³, Gao Dehai^3,^*()

¹Department of Hepatobiliary Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China
²Department of General Surgery, Fifth People's Hospital of Jinan, Jinan 250022, China
³Department of Achievements Transformation and Industry (Serving Local Economic Office), Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250021, China

Received:2020-06-29 Revised:2020-09-09 Online:2021-03-08 Published:2021-03-25
Contact: Gao Dehai E-mail:sdywyjy@126.com
Supported by:
Academic Promotion Program of Shandong First Medical University(2019QL004);Jinan “Twenty Universities” Project Funding(2019GXRC020);Major Science and Technology Innovation Project of Shandong Province(2017CXGC1204)

摘要/Abstract

摘要：

循环肿瘤细胞(CTC)作为一种新兴的肿瘤标志物,其稀有性和异质性增加了检测的难度。近年来依据生物物理特性、生物化学特性及微流控的CTC富集技术不断发展,促进了CTC在恶性肿瘤辅助诊断、临床治疗和预后评价等方面的研究和应用。CTC的检测目前仍存在一些不足,但随着多学科交叉融合,CTC在恶性肿瘤的辅助诊断、治疗等方面将发挥更大的作用。

关键词: 肿瘤细胞, 循环, 生物标记, 细胞学技术, 诊断

Abstract:

As an emerging tumor marker, the rarity and heterogeneity of circulating tumor cells (CTCs) increase the difficulty of detection. In recent years, CTCs enrichment technology based on biophysical, biochemical and microfluidic properties has been continuously developed, which has promoted the research and application of CTCs in malignant tumors diagnosis, clinical treatment and prognosis evaluation. Although there are still some deficiencies in the detection of CTCs, with the interdisciplinary integration, CTCs will play increasingly important roles in the diagnosis and treatment of malignant tumors.

Key words: Neoplastic cells, circulating, Biomarkers, Cytological techniques, Diagnosis

宁大为, 欧洋, 崔凯, 李胜, 高德海. 循环肿瘤细胞的富集方法与临床应用[J]. 国际肿瘤学杂志, 2021, 48(3): 167-171.

Ning Dawei, Ou Yang, Cui Kai, Li Sheng, Gao Dehai. Enrichment methods and clinical application of circulating tumor cells[J]. Journal of International Oncology, 2021, 48(3): 167-171.

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循环肿瘤细胞的富集方法与临床应用

Enrichment methods and clinical application of circulating tumor cells

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