国际肿瘤学杂志 ›› 2020, Vol. 47 ›› Issue (12): 732-736.doi: 10.3760/cma.j.cn371439-20200419-00110

• 综述 • 上一篇    下一篇

CXCR1与恶性肿瘤的相关性

刘彦权, 沈建箴()   

  1. 福建省血液病研究所 国家及福建省血液病学重点实验室 福建医科大学附属协和医院血液内科,福州 350001
  • 收稿日期:2020-04-19 修回日期:2020-05-18 出版日期:2020-12-08 发布日期:2021-01-28
  • 通讯作者: 沈建箴 E-mail:doctorsjz@163.com
  • 基金资助:
    福建省科技创新联合资金项目(2018Y9010);福建省卫生计生科研人才培养项目(2016-ZQN-29);福建省卫生计生科研人才培养项目(2018-ZQN-40)

Correlation between CXCR1 and malignant tumors

Liu Yanquan, Shen Jianzhen()   

  1. Fujian Institute of Hematology, National and Fujian Provincial Key Laboratory of Hematology, Department of Hematopathology, Fujian Medical University Union Hospital, Fuzhou 350001, China
  • Received:2020-04-19 Revised:2020-05-18 Online:2020-12-08 Published:2021-01-28
  • Contact: Shen Jianzhen E-mail:doctorsjz@163.com
  • Supported by:
    Joints Funds for the Innovation of Science and Technology of Fujian Province(2018Y9010);Health and Family Planning Research Personnel Training Program of Fujian Province(2016-ZQN-29);Health and Family Planning Research Personnel Training Program of Fujian Province(2018-ZQN-40)

摘要:

作为G蛋白偶联受体超家族的重要成员,CXC趋化因子受体1(CXCR1)是CXC趋化因子白细胞介素-8最重要且颇具亲和力的受体之一。CXCR1常表达于中性粒细胞、单核细胞、T细胞等细胞表面,并且可与CXC趋化因子配体(CXCL)6、CXCL7、CXCL8相结合。研究发现CXCR1在促进恶性肿瘤转移、化疗耐药以及维持肿瘤干细胞特性中发挥至关重要的作用,下调CXCR1表达能显著抑制恶性肿瘤的生物学特性。目前学术界将CXCR1视为恶性肿瘤的原癌基因,CXCR1有望成为恶性肿瘤诊断和治疗的潜在靶点。

关键词: 受体, 趋化因子, 受体, 白细胞介素8A, 趋化因子, CXC, 肿瘤

Abstract:

As an important member of the G protein coupled receptor superfamily, CXC chemokine receptor 1 (CXCR1) is also one of the most important and affinity receptors for CXC chemokine interleukin 8. CXCR1 is often expressed on the surface of cells such as neutrophils, monocytes and T cells, which can bind to CXC chemokine ligand (CXCL)6, CXCL7 and CXCL8. Studies have found that CXCR1 plays a vital role in promoting the metastasis, chemotherapy resistance and maintaining the characteristics of tumor stem cells. Down-regulating the expression of CXCR1 can significantly inhibit the biological characteristics of malignant tumors. At present, the academic field regards CXCR1 as the proto-oncogene of malignant tumors. CXCR1 is expected to become a potential target for the diagnosis and treatment of malignant tumors.

Key words: Receptors, chemokine, Receptors, interleukin-8A, Chemokines, CXC, Neoplasms