G6PD与肿瘤

doi:10.3760/cma.j.cn371439-20200401-00109

摘要/Abstract

摘要：

葡萄糖-6-磷酸脱氢酶(G6PD)是磷酸戊糖途径的关键酶,参与体内多种代谢过程及氧化还原平衡。近年来研究发现,G6PD在多种肿瘤组织中活性升高,其可调控肿瘤细胞的增殖和凋亡、血管生成、远处转移及放化疗抵抗等,在肿瘤发生发展中起着重要作用,G6PD有望成为新兴的肿瘤治疗靶点。

关键词: 肿瘤, 磷酸葡糖脱氢酶, 肿瘤形成过程, 生物标志物

Abstract:

Glucose-6-phosphate dehydrogenase (G6PD) is the key enzyme of the pentose phosphate pathway, participating in several metabolic processes and redox balance. Recently, studies show that kinds of tumor tissues have a high level of G6PD, which regulates cell proliferation and apoptosis, angiogenesis, metastasis and chemoradiotherapy resistance and plays a crucial role in tumor progression. Furthermore, G6PD may provide a promising therapeutic target for tumor.

Key words: Neoplasms, Phosphogluconate dehydrogenase, Neoplastic processes, Biomarkers

王钟, 李智宇, 李晨媛, 孙思, 孙圣荣. G6PD与肿瘤[J]. 国际肿瘤学杂志, 2020, 47(12): 728-731.

Wang Zhong, Li Zhiyu, Li Chenyuan, Sun Si, Sun Shengrong. G6PD and tumors[J]. Journal of International Oncology, 2020, 47(12): 728-731.

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G6PD与肿瘤

G6PD and tumors

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