国际肿瘤学杂志

国际肿瘤学杂志 ›› 2018, Vol. 45 ›› Issue (4): 229-233.doi: 10.3760/cma.j.issn.1673-422X.2018.04.010

• 综述 • 上一篇    下一篇

Fibulin家族成员在肿瘤发生发展中的作用

罗旭,孙赟晨,朱樑,胡江峰   

  1. 200003 上海，第二军医大学附属长征医院消化内科（罗旭、孙赟晨、朱樑）；上海市第一人民医院消化内科（胡江峰）
  • 出版日期:2018-04-08 发布日期:2018-05-16
  • 通讯作者: 朱樑，Email: czzhuliang@smmu.edu.cn；胡江峰，Email: doctorhjf@foxmail.com E-mail:czzhuliang@smmu.edu.cn; doctorhjf@foxmail.com
  • 基金资助:

    国家自然科学基金（11472300）

Roles of Fibulin family members in the genesis and development of tumors

Luo Xu, Sun Yunchen, Zhu Liang, Hu Jiangfeng   

  1. Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
  • Online:2018-04-08 Published:2018-05-16
  • Contact: Zhu Liang, Email: czzhuliang@smmu.edu.cn; Hu Jiangfeng, Email: doctorhjf@foxmail.com E-mail:czzhuliang@smmu.edu.cn; doctorhjf@foxmail.com
  • Supported by:

    National Natural Science Foundation of China (11472300)

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摘要： Fibulin家族是一类分泌性的糖蛋白，属于细胞外基质蛋白，7个家族成员广泛分布于基底膜、弹性纤维和疏松结缔组织中，广泛参与细胞形态、生长、黏附的调节。当Fibulin发生失调时，能够引起一系列疾病，如皮肤松弛症、牙齿发育不良、各种肿瘤等。研究表明，Fibulin-1在纤维肉瘤、胃癌、肝癌中表达异常；Fibulin-2在乳腺癌中表达下调，在肺癌中表达上调等；其余家族成员在各种肿瘤组织中也出现异常表达现象，提示Fibulin家族成员在肿瘤的发生发展中起着重要的调控作用。

关键词: 肿瘤, 细胞外基质, Fibulin

Abstract: The Fibulin family is a kind of secreted glycoprotein, belonging to the extracellular matrix protein. A total of 7 family members are widely distributed in basement membrane, elastic fiber and loose connective tissue. The Fibulin family is widely involved in the regulation of cell morphology, growth and adhesion. When Fibulin is disturbed, it can cause a range of diseases, such as skin laxity, tooth hypoplasia and various tumors. The researches show that Fibulin-1 is expressed abnormally in fibrosarcoma, gastric cancer and liver cancer, and the expression of Fibulin-2 is downregulated in breast cancer and upregulated in lung cancer. The other members of the family also show abnormal expression in various tumor tissues, which indicates the members of the Fibulin family play important roles in the genesis and development of tumors.

Key words: Neoplasms, Extracellular matrix, Fibulin