国际肿瘤学杂志

国际肿瘤学杂志 ›› 2018, Vol. 45 ›› Issue (4): 220-222.doi: 10.3760/cma.j.issn.1673-422X.2018.04.007

• 综述 • 上一篇    下一篇

长非编码RNA在肿瘤中的作用机制

李智,许静凯,张博   

  1. 230601 合肥，安徽医科大学附属第二医院肿瘤科（李智、张博）；安徽医科大学附属第一医院皮肤科（李智、许静凯）
  • 出版日期:2018-04-08 发布日期:2018-05-16
  • 通讯作者: 张博，Email： alvinbo@163.com E-mail:alvinbo@163.com
  • 基金资助:

    安徽省高等学校自然科学研究（KJ2017A181）

Mechanisms of long non-coding RNAs in tumors

Li Zhi, Xu Jingkai, Zhang Bo   

  1. Department of Oncology, Second Affiliated Hospital of Anhui Medical University; Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei 230601, China
  • Online:2018-04-08 Published:2018-05-16
  • Contact: Zhang Bo, Email: alvinbo@163.com E-mail:alvinbo@163.com
  • Supported by:

    Natural Science Foundation of Higher Education of Anhui Province of China （KJ2017A181）

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摘要： 长非编码RNA（lncRNA）可以通过调节细胞中蛋白的表达、信号通路及调控细胞周期等不同方式促进或抑制胰腺癌、肺癌、胃癌、乳腺癌的发生发展。深入研究不同lncRNA在肿瘤中的作用机制，可能为肿瘤诊疗提供新的方法。

关键词: 胰腺肿瘤, 肺肿瘤, 胃肿瘤, 乳腺肿瘤, 长非编码RNA

Abstract: Long noncoding RNAs (lncRNAs) can promote or inhibit the occurrence and development of pancreatic cancer, lung cancer, gastric cancer and breast cancer by regulating the expression of protein, signal pathway and cell cycle in different ways. Further studies of mechanisms of different lncRNAs in tumors may provide new methods for the diagnosis and treatment of cancers.

Key words: Pancreatic neoplasms, Lung neoplasms, Stomach neoplasms, Breast neoplasms, Long non-coding RNA