国际肿瘤学杂志

国际肿瘤学杂志 ›› 2018, Vol. 45 ›› Issue (4): 223-225.doi: 10.3760/cma.j.issn.1673-422X.2018.04.008

• 综述 • 上一篇    下一篇

 长非编码RNA在肿瘤耐药发展中的作用

周童,贾颜鸿,毕也,张泽兵   

  1. 130021 长春，吉林大学口腔医院病理科
  • 出版日期:2018-04-08 发布日期:2018-05-16
  • 通讯作者: 张泽兵，Email: zebing@jlu.edu.cn E-mail:zebing@jlu.edu.cn
  • 基金资助:

    吉林省自然科学基金（20150101174JC）

Role of long non-coding RNA in tumor drug resistance development

Zhou Tong, Jia Yanhong, Bi Ye, Zhang Zebing   

  1. Department of Pathology, Hospital of Stomatology, Jilin University, Changchun 130021, China
  • Online:2018-04-08 Published:2018-05-16
  • Contact: Zhang Zebing, Email: zebing@jlu.edu.cn E-mail:zebing@jlu.edu.cn
  • Supported by:

    Natural Science Foundation of Jilin Province of China (20150101174JC)

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摘要： 随着长非编码RNA（lncRNA）的作用与种类被不断地研究与阐明，lncRNA与肿瘤耐药的关系越来越受到关注。研究发现lncRNA通过改变DNA修复与细胞周期、药物外排系统、药物代谢、细胞凋亡和上皮间质转化等过程参与肿瘤耐药。lncRNA有望成为新的生物学标志物，为肿瘤的诊断、治疗和预后评估提供新的途径。

关键词: RNA, 肿瘤, 抗药性

Abstract: With the continuous research and elucidation of the role and species of long noncoding RNAs (lncRNAs), the relationship between lncRNAs and cancer resistance has been paid more and more attention by researchers. Studies find that lncRNAs are involved in tumor drug resistance by altering DNA repair and cell cycle, drug delivery system, drug metabolism, cell apoptosis and epithelial interstitial transformation. lncRNAs are expected to be a new biological marker, which provids a new way to diagnose, treat and evaluate the prognosis of cancer.

Key words: RNA, Neoplasms, Drug resistance