Notch信号通路在黑色素瘤生长、转移中的作用及机制

doi:10.3760/cma.j.issn.1673-422X.2018.10.013

国际肿瘤学杂志 ›› 2018, Vol. 45 ›› Issue (10): 635-638.doi: 10.3760/cma.j.issn.1673-422X.2018.10.013

Notch信号通路在黑色素瘤生长、转移中的作用及机制

夏得淳,康晓静

832000 石河子大学医学院临床医学系（夏得淳）；新疆维吾尔自治区人民医院皮肤性病科（夏得淳、康晓静）

收稿日期:2018-05-24 出版日期:2018-10-08 发布日期:2018-12-21
通讯作者: 康晓静 E-mail:drkangxj666@163.com
基金资助:
新疆维吾尔自治区自然科学基金（2016D01C101）

Role and mechanism of Notch signaling pathway in melanoma growth and metastasis

Xia Dechun, Kang Xiaojing

Department of Clinical Medicine, Shihezi University School of Medicine, Shihezi 832000, China; Department of Dermatology, People′s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China

Received:2018-05-24 Online:2018-10-08 Published:2018-12-21
Contact: Kang Xiaojing E-mail:drkangxj666@163.com
Supported by:
Natural Science Foundation of Xinjiang Uygur Autonomous Region of China (2016D01C101)

摘要/Abstract

摘要： 恶性黑色素瘤是皮肤恶性肿瘤之一，具有高度侵袭性和较强的转移能力，其发病与多种信号通路的异常传导有关，但具体机制尚不完全清楚。Notch信号通路的异常激活与黑色素瘤发病关系密切，其可通过维持肿瘤细胞存活、促进肿瘤血管生成、增强肿瘤细胞的黏附力和侵袭力等方式促进黑色素瘤细胞的生长和转移。进一步了解Notch信号通路的作用机制可能为黑色素瘤的治疗提供新的靶点。

关键词: 黑色素瘤, 生长, 肿瘤转移, Notch信号通路

Abstract: Malignant melanoma is one of the malignant tumors in the skin, which has high invasiveness and stronger ability of metastasis. Its pathogenesis is related to the abnormal conduction of many signal pathways, while the specific mechanism is not completely clear. The abnormal activation of Notch signaling pathway is closely related to the pathogenesis of melanoma. Notch signaling pathway can promote the growth and metastasis of melanoma through maintaining the survival of tumor cells, promoting tumor angiogenesis and enhancing the adhesion and invasiveness of tumor cells. Further understanding of the mechanism of Notch signaling pathway may provide a new target for the treatment of melanoma.

Key words: Melanoma, Growth, Neoplasm metastasis, Notch signaling pathway

夏得淳,康晓静. Notch信号通路在黑色素瘤生长、转移中的作用及机制[J]. 国际肿瘤学杂志, 2018, 45(10): 635-638.

Xia Dechun, Kang Xiaojing. Role and mechanism of Notch signaling pathway in melanoma growth and metastasis[J]. Journal of International Oncology, 2018, 45(10): 635-638.

参考文献

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Notch信号通路在黑色素瘤生长、转移中的作用及机制

Role and mechanism of Notch signaling pathway in melanoma growth and metastasis

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